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anti-ADRA2A antibody :: Rabbit Adrenergic Receptor, Alpha 2a Polyclonal Antibody

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Catalog # MBS619330
Unit / Price
  0.1 mL  /  $870 +1 FREE 8GB USB
anti-ADRA2A antibody
Product Name

Adrenergic Receptor, Alpha 2a (ADRA2A), Polyclonal Antibody

Also Known As

Adrenergic Receptor, Alpha 2a (A2aAR)

Product Synonym Names
Anti -Adrenergic Receptor, Alpha 2a (A2aAR)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 10; NC_000010.10 (112836790..112840665). Location: 10q24-q26
OMIM
104210
3D Structure
ModBase 3D Structure for P08913
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes human A2aAR. at~45kD. Species Crossreactivity
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 1mg/ml BSA, 0.05% sodium azide, before the addition of glycerol to 40%.
Immunogen
Synthetic peptide corresponding to aa218-235 [RIYQIAKRRTRVPPSRRG] of human A2aAR. This sequence is completely conserved in mouse, rat and porcine A2aAR.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-ADRA2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ADRA2A antibody
Alpha 2A, 2B, and 2C adrenergic receptors are seven transmembrane receptors that couple to inhibitory G-proteins.
Product Categories/Family for anti-ADRA2A antibody
Applications Tested/Suitable for anti-ADRA2A antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ADRA2A antibody
Suitable for use in Immunohistochemistry and Western Blot.
Dilution: Immunohistochemistry (paraffin sections): 1:500
Western Blot: 1:250
NCBI/Uniprot data below describe general gene information for ADRA2A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,957 Da[Similar Products]
NCBI Official Full Name
alpha-2A adrenergic receptor
NCBI Official Synonym Full Names
adrenergic, alpha-2A-, receptor
NCBI Official Symbol
ADRA2A  [Similar Products]
NCBI Official Synonym Symbols
ADRA2; ADRAR; ZNF32; ADRA2R; ALPHA2AAR
  [Similar Products]
NCBI Protein Information
alpha-2A adrenergic receptor; OTTHUMP00000020485; alpha-2A adrenoceptor; alpha-2AAR subtype C10; alpha-2A adrenoreceptor; alpha-2 adrenergic receptor subtype C10; alpha-2-adrenergic receptor, platelet type
UniProt Protein Name
Alpha-2A adrenergic receptor
UniProt Synonym Protein Names
Alpha-2 adrenergic receptor subtype C10; Alpha-2A adrenoreceptor
UniProt Gene Name
ADRA2A  [Similar Products]
UniProt Synonym Gene Names
ADRA2R; ADRAR  [Similar Products]
UniProt Entry Name
ADA2A_HUMAN
NCBI Summary for ADRA2A
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq]
UniProt Comments for ADRA2A
ADRA2A: Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 10q25.2

Cellular Component: integral to plasma membrane; basolateral plasma membrane; cytoplasm; plasma membrane; synapse; receptor complex

Molecular Function: protein binding; protein homodimerization activity; alpha-2C adrenergic receptor binding; protein heterodimerization activity; thioesterase binding; alpha2-adrenergic receptor activity; alpha-1B adrenergic receptor binding; norepinephrine binding; epinephrine binding; protein kinase binding; heterotrimeric G-protein binding

Biological Process: fear response; negative regulation of calcium ion-dependent exocytosis; positive regulation of potassium ion transport; female pregnancy; thermoception; signal transduction; positive regulation of vasodilation; glucose homeostasis; positive regulation of membrane protein ectodomain proteolysis; Rho protein signal transduction; negative regulation of insulin secretion; intestinal absorption; positive regulation of MAP kinase activity; negative regulation of cAMP biosynthetic process; negative regulation of lipid catabolic process; positive regulation of epidermal growth factor receptor activity; positive regulation of cell proliferation; DNA replication; positive regulation of cytokine production; platelet activation; negative regulation of calcium ion transport; activation of protein kinase B; negative regulation of adenylate cyclase activity; cellular response to hormone stimulus; G-protein coupled receptor protein signaling pathway; regulation of vasoconstriction; Ras protein signal transduction; activation of protein kinase activity; energy reserve metabolic process; negative regulation of epinephrine secretion; cell motility; blood coagulation; actin cytoskeleton organization and biogenesis; regulation of insulin secretion; acute inflammatory response; positive regulation of cell migration
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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