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anti-AGRN antibody :: Rabbit AGRN Polyclonal Antibody

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Catalog # MBS415546
Unit / Price
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  0.1 mg  /  $230 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

AGRN, Polyclonal Antibody

Full Product Name

Anti-AGRN Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
103320
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat. Not yet tested in other species.
Purity/Purification
Affinity purified
Form/Format
Liquid
Concentration
100ug/100ul (lot specific)
Storage Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Immunogen
Rabbit polyclonal AGRN antibody was raised against a peptide from N terminal residues of human AGRN protein.
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Other Notes
Small volumes of anti-AGRN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AGRN antibody
This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. [provided by RefSeq, Aug 2011]
Applications Tested/Suitable for anti-AGRN antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-AGRN antibody
Peptide ELISA titer: 1:10,000-1:40,000
Immunohistochemistry: 1:100-500
Optimal dilutions/concentrations should be determined by the end user.

Immunohistochemistry (IHC) of anti-AGRN antibody
anti-AGRN antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for AGRN. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
216,733 Da
NCBI Official Full Name
AGRN protein, partial
NCBI Official Synonym Full Names
agrin
NCBI Official Symbol
NCBI Official Synonym Symbols
CMSPPD
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NCBI Protein Information
agrin; agrin proteoglycan
UniProt Protein Name
Agrin
Protein Family
UniProt Gene Name
UniProt Entry Name
AGRIN_HUMAN
NCBI Summary for AGRN
This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
UniProt Comments for AGRN
AGRN: Plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Ligand of the MUSK signaling complex that directly binds LRP4 in this complex and induces the phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Defects in AGRN are a cause of myasthenia, limb-girdle, familial (LGM). A congenital myasthenic syndrome characterized by a typical 'limb girdle' pattern of muscle weakness with small, simplified neuromuscular junctions but normal acetylcholine receptor and acetylcholinesterase function.

Protein type: Cell adhesion; Extracellular matrix; Secreted; Cell development/differentiation; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.33

Cellular Component: extracellular matrix; extracellular space; lysosomal lumen; cell surface; Golgi lumen; cytoplasm; plasma membrane; integral to membrane; extracellular region; synapse; basal lamina; cell junction

Molecular Function: heparan sulfate proteoglycan binding; protein binding; structural constituent of cytoskeleton; acetylcholine receptor regulator activity; laminin binding; calcium ion binding; sialic acid binding

Biological Process: positive regulation of filopodium formation; clustering of voltage-gated sodium channels; phototransduction, visible light; axon guidance; extracellular matrix organization and biogenesis; acetylcholine receptor signaling, muscarinic pathway; glycosaminoglycan metabolic process; neurotransmitter receptor metabolic process; pathogenesis; positive regulation of synaptic growth at neuromuscular junction; signal transduction; receptor clustering; chondroitin sulfate metabolic process; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; plasma membrane organization and biogenesis; positive regulation of neuron apoptosis; carbohydrate metabolic process; synapse organization and biogenesis; positive regulation of transcription from RNA polymerase II promoter; regulation of receptor activity; retinoid metabolic process; neuromuscular junction development

Disease: Myasthenic Syndrome, Congenital, With Pre- And Postsynaptic Defects
Product References and Citations for anti-AGRN antibody
(1) Lim,J., Hao,T., Shaw,C., etal. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.Cell 125 (4), 801-814 (2006)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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Products associated with anti-AGRN antibody
 Reference Product  PubMed Publications
 ATP1A3 antibody  >1 publications with AGRN and ATP1A3
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