NP_001005353.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 25 kDa Predicted: 26 kDa
NCBI Official Full Name
adenylate kinase 4, mitochondrial isoform a
NCBI Official Synonym Full Names
adenylate kinase 4
NCBI Protein Information
adenylate kinase 4, mitochondrial
UniProt Protein Name
Adenylate kinase 4, mitochondrial
UniProt Synonym Protein Names
Adenylate kinase 3-likeUniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03170; GTP:AMP phosphotransferase AK4UniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03170
UniProt Synonym Gene Names
AK3; AK3L1UniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03170; AK 4 [Similar Products]
NCBI Summary for AK4
This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. [provided by RefSeq, Jul 2008]
UniProt Comments for AK4
Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.
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Pathways associated with anti-AK4 antibody
Diseases associated with anti-AK4 antibody
Organs/Tissues associated with anti-AK4 antibody
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