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anti-AMHR2 antibody :: Rabbit AMHR2 Polyclonal Antibody

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Catalog # MBS9200710
Unit / Price
  0.08 mL  /  $150 +1 FREE 8GB USB
  0.4 mL  /  $340 +1 FREE 8GB USB
Product Name

AMHR2, Polyclonal Antibody

Popular Item
Also Known As

AMHR2 Antibody (C-term)

Product Synonym Names
Anti-Muellerian hormone type-2 receptor; Anti-Muellerian hormone type II receptor; AMH type II receptor; MIS type II receptor; MISRII; MRII; AMHR2; AMHR; MISR2
Antibody/Peptide Pairs
AMHR2 peptide (MBS9226599) is used for blocking the activity of AMHR2 antibody (MBS9200710)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
374-402
Immunogen Sequence Length
478
OMIM
261550
3D Structure
ModBase 3D Structure for Q16671
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human (Predicted Reactivity: Mouse, Rat)
Specificity
This AMHR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 374-402 amino acids from the C-terminal region of human AMHR2.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Preparation and Storage
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-AMHR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AMHR2 antibody
The AMH receptor (AMHR or AMHR2) is a serine/threonine kinase with a single transmembrane domain belonging to the family of type II receptors for TGF-beta-related proteins. Anti-Mullerian hormone (AMH) and its receptor are involved in the regression of Mullerian ducts in male fetuses. Male sex differentiation is mediated by 2 discrete hormones produced by the fetal testis. Testosterone, produced by Leydig cells, virilizes the external genitalia and promotes prostatic growth; anti-Mullerian hormone (AMH) results in regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes.
Product Categories/Family for anti-AMHR2 antibody
Applications Tested/Suitable for anti-AMHR2 antibody
Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS)
Application Notes for anti-AMHR2 antibody
WB~~1:1000
FC~~1:10~50

Western Blot (WB) of anti-AMHR2 antibody
Western blot analysis of AMHR2 Antibody (C-term) in CEM cell line lysates (35ug/lane).AMHR2 (arrow) was detected using the purified Pab.
anti-AMHR2 antibody Western Blot (WB) (WB) image
Flow Cytometry (FC/FACS) of anti-AMHR2 antibody
Flow cytometric analysis of CEM cells using AMHR2 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-AMHR2 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
Western Blot (WB) of anti-AMHR2 antibody
Western blot analysis of AMHR2 Antibody (C-term) in CEM cell line lysates (35ug/lane).AMHR2 (arrow) was detected using the purified Pab.
anti-AMHR2 antibody Western Blot (WB) (WB) image
Flow Cytometry (FC/FACS) of anti-AMHR2 antibody
Flow cytometric analysis of CEM cells using AMHR2 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-AMHR2 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
NCBI/Uniprot data below describe general gene information for AMHR2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
Human (Predicted Reactivity: Mouse, Rat)NP_001158163.1; NP_065434.1[Other Products]
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
anti-Muellerian hormone type-2 receptor isoform 2
NCBI Official Synonym Full Names
anti-Mullerian hormone receptor, type II
NCBI Official Symbol
AMHR2  [Similar Products]
NCBI Official Synonym Symbols
AMHR; MRII; MISR2; MISRII
  [Similar Products]
NCBI Protein Information
anti-Muellerian hormone type-2 receptor
UniProt Protein Name
Anti-Muellerian hormone type-2 receptor
UniProt Synonym Protein Names
Anti-Muellerian hormone type II receptor; AMH type II receptor; MIS type II receptor; MISRII; MRII
UniProt Gene Name
AMHR2  [Similar Products]
UniProt Synonym Gene Names
AMHR; MISR2; AMH type II receptor; MISRII; MRII  [Similar Products]
UniProt Entry Name
AMHR2_HUMAN
NCBI Summary for AMHR2
This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2009]
UniProt Comments for AMHR2
MISR2: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Protein type: Kinase, protein; Protein kinase, TKL; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); EC 2.7.11.30; TKL group; STKR family; Type2 subfamily

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: integral to plasma membrane

Molecular Function: protein binding; hormone binding; transforming growth factor beta receptor activity, type II; metal ion binding; receptor activity; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: Mullerian duct regression; transforming growth factor beta receptor signaling pathway; signal transduction; protein amino acid phosphorylation; sex differentiation

Disease: Persistent Mullerian Duct Syndrome, Types I And Ii
Product References and Citations for anti-AMHR2 antibody
Picard, J.Y., et al., J. Soc. Biol. 196(3):217-221 (2002).
Teixeira, J., et al., Endocr. Rev. 22(5):657-674 (2001).
Imbeaud, S., et al., Nat. Genet. 11(4):382-388 (1995).
Visser, J.A., et al., Biochem. Biophys. Res. Commun. 215(3):1029-1036 (1995).
Sinisi, A.A., et al., J. Endocrinol. Invest. 26 (3 Suppl), 23-28 (2003).

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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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