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anti-APBA1 antibody :: Rabbit APBA1 Polyclonal Antibody

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Catalog # MBS9609519
Unit / Price
  0.1 mL  /  $255 +1 FREE 8GB USB
  0.2 mL  /  $295 +1 FREE 8GB USB
Western Blot (WB)
Product Name

APBA1, Polyclonal Antibody

Popular Item
Also Known As

APBA1 Antibody

Product Synonym Names
Adapter protein X11 alpha; Adapter protein X11alpha; Amyloid beta A4 precursor protein-binding family A member 1; Apba1; APBA1_HUMAN; Mint 1; Mint-1; Neuron specific X11 protein; Neuron-specific X11 protein; Neuronal Munc18 1 interacting protein 1; Neuronal Munc18-1-interacting protein 1; UROP11; x11; X11alpha
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
837
3D Structure
ModBase 3D Structure for Q02410
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
APBA1 antibody detects endogenous levels of total APBA1
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human APBA1
Subcellular Location
Nucleus; Golgi Apparatus
Tissue Specificity
Brain and spinal cord. Isoform 2 is expressed in testis and brain, but not detected in lung, liver or spleen.
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-APBA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-APBA1 antibody
Function: Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.
Subunit Structure: Part of a multimeric complex containing Munc18-1 and syntaxin-1. Also part of the brain-specific heterotrimeric complex LIN-10/X11-alpha, LIN-2/CASK, and LIN7. Both isoform 1 and isoform 2 bind to the cytoplasmic domain of amyloid protein (APP). Interacts (via PDZ 1 and 2 domains) with FSPB. Isoform 2, but not isoform 1, interacts (via its truncated PID domain) with active, GTP-bound RAB6A and RAB6B.
Similarity: Composed of an N-terminal domain that binds Munc18-1 and LIN-2/CASK, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the amyloid-beta precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.The autoinhibitory helix linker occludes the APP binding site.The PID domain, truncated by 11 amino acids, as observed in isoform 2, but not full-length, mediates the interaction with RAB6A and RAB6B.
Applications Tested/Suitable for anti-APBA1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-APBA1 antibody
WB: 1:1000-3000

Western Blot (WB) of anti-APBA1 antibody
Western blot analysis of APBA1 using HeLa whole cell lysates
anti-APBA1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for APBA1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 93 kDa
Predicted: 93 kDa
NCBI Official Full Name
amyloid-beta A4 protein-binding family A member 1
NCBI Official Synonym Full Names
amyloid beta precursor protein binding family A member 1
NCBI Official Symbol
APBA1  [Similar Products]
NCBI Official Synonym Symbols
X11; X11A; LIN10; MINT1; D9S411E; X11ALPHA
  [Similar Products]
NCBI Protein Information
amyloid-beta A4 precursor protein-binding family A member 1
UniProt Protein Name
Amyloid-beta A4 precursor protein-binding family A member 1
UniProt Synonym Protein Names
Adapter protein X11alpha; Neuron-specific X11 protein; Neuronal Munc18-1-interacting protein 1; Mint-1
UniProt Gene Name
APBA1  [Similar Products]
UniProt Synonym Gene Names
MINT1; X11; Mint-1  [Similar Products]
NCBI Summary for APBA1
The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2008]
UniProt Comments for APBA1
Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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