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anti-NOL3 antibody :: Rabbit Apoptosis repressor with CARD Polyclonal Antibody

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Catalog # MBS175694
Unit / Price
  0.1 mg  /  $280 +1 FREE 8GB USB
Western Blot (WB)
Product Name

Apoptosis repressor with CARD (NOL3), Polyclonal Antibody

Also Known As

Anti-Apoptosis repressor with CARD antibody

Product Synonym Names
Nucleolar protein 3; nucleolar protein 3(apoptosis repressor with CARD doma); Apoptosis repressor with CARD antibody; ARC antibody; Muscle enriched cytoplasmic protein antibody; Muscle-enriched cytoplasmic protein antibody; MYC antibody; MYP antibody; Nol3 antibody; NOL3_HUMAN antibody; NOP antibody; Nop30 antibody; Nucleolar protein 3(apoptosis repressor with CARD domain) antibody; Nucleolar protein 3 antibody; Nucleolar protein of 30 kDa antibody
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
219
OMIM
gene 614937
3D Structure
ModBase 3D Structure for O60936
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Immunogen affinity purified.
Form/Format
Lyophilized
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human Apoptosis repressor with CARD (91-106aa WDWQHVGPGYRDRSYD), identical to the related rat sequence, and different from the related mouse sequence by one amino acid.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-NOL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NOL3 antibody
Description: Rabbit IgG polyclonal antibody for Nucleolar protein 3(NOL3) detection. Tested with WB in Human, Mouse, Rat.
Background: NOL3(Nucleolar protein 3), also known as ARC, NOP30, CARD2 and MYP, is a protein that in humans is encoded by the NOL3 gene. NOL3 has been shown to interact with SFRS9 and Caspase 8. By genomic sequence analysis, Stoss et al.(1999) determined that the NOL3 gene, which encodes NOP30 and MYP and which they called NOP, is composed of 4 exons. The alternative 5-prime splice site that generates the 2 isoforms is located in exon 2. It is reported that expression of the ARC cDNA encoding the smaller transcript inhibited apoptosis in a dose-dependent manner when coexpressed with CASP8 but not when coexpressed with CASP9. ARC also inhibited apoptosis induced by stimulation of CD95/FAS, tumor necrosis factor receptor-1, and TRAMP/death receptor-3. Enzymatic analysis showed that ARC inhibits the enzymatic activity of CASP8. Immunoprecipitation and immunoblot analysis indicated that ARC interacts with CASP2 and CASP8 through its N-terminal death effector domain but does not interact with CASP1, CASP3, or CASP9.
Applications Tested/Suitable for anti-NOL3 antibody
Western Blot (WB)

Western Blot (WB) of anti-NOL3 antibody
Anti-Apoptosis repressor with CARD antibody, MBS175694, Western blotting
Lane 1: SMMC Cell Lysate
Lane 2: A549 Cell Lysate
Lane 3: U87 Cell Lysate
Lane 4: HELA Cell Lysate
Lane 5: MCF-7 Cell Lysate
Lane 6: Rat Liver Tissue Lysate

anti-NOL3 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for NOL3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,355 Da
NCBI Official Full Name
Nucleolar protein 3
NCBI Official Synonym Full Names
nucleolar protein 3 (apoptosis repressor with CARD domain)
NCBI Official Symbol
NCBI Official Synonym Symbols
ARC; FCM; MYP; NOP; NOP30
  [Similar Products]
NCBI Protein Information
nucleolar protein 3; nucleolar protein of 30 kDa; muscle-enriched cytoplasmic protein
UniProt Protein Name
Nucleolar protein 3
UniProt Synonym Protein Names
Apoptosis repressor with CARD; Muscle-enriched cytoplasmic protein; Myp; Nucleolar protein of 30 kDa; Nop30
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
ARC; NOP; Myp; Nop30  [Similar Products]
UniProt Entry Name
NOL3_HUMAN
NCBI Summary for NOL3
This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
UniProt Comments for NOL3
Isoform 1: May be involved in RNA splicing.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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