NP_001238833.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated: 69kDa; 74kDa; 75kDa Observed: 74kDa
NCBI Official Full Name
DCC-interacting protein 13-beta isoform 2
NCBI Official Synonym Full Names
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
NCBI Official Synonym Symbols
NCBI Protein Information
DCC-interacting protein 13-beta
UniProt Protein Name
DCC-interacting protein 13-beta
UniProt Synonym Protein Names
Adapter protein containing PH domain, PTB domain and leucine zipper motif 2
UniProt Synonym Gene Names
NCBI Summary for APPL2
The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011]
UniProt Comments for APPL2
Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction.
Research Articles on APPL2
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Products associated with anti-APPL2 antibody
Pathways associated with anti-APPL2 antibody
Diseases associated with anti-APPL2 antibody
Organs/Tissues associated with anti-APPL2 antibody
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