NP_036196.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
lens fiber major intrinsic protein
NCBI Official Synonym Full Names
major intrinsic protein of lens fiber
NCBI Official Synonym Symbols
AQP0; LIM1; MP26; MIP26; CTRCT15 [Similar Products]
NCBI Protein Information
lens fiber major intrinsic protein
UniProt Protein Name
Lens fiber major intrinsic protein
UniProt Synonym Protein Names
Aquaporin-0; MIP26; MP26
UniProt Synonym Gene Names
NCBI Summary for AQP0
Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13. [provided by RefSeq, Jul 2008]
UniProt Comments for AQP0
Water channel (PubMed:24120416). Channel activity is down-regulated by CALM when cytoplasmic Ca2+ levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (PubMed:24120416).
Research Articles on AQP0
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Products associated with anti-AQP0 antibody
Pathways associated with anti-AQP0 antibody
Diseases associated with anti-AQP0 antibody
Organs/Tissues associated with anti-AQP0 antibody
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