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anti-ARHGAP22 antibody :: Rabbit ARHGAP22 Polyclonal Antibody

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Catalog # MBS821095
Unit / Price
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  0.03 mL  /  $155 +1 FREE 8GB USB
  0.1 mL  /  $220 +1 FREE 8GB USB
  0.2 mL  /  $295 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

ARHGAP22, Polyclonal Antibody

Popular Item
Full Product Name

Anti-ARHGAP22 Antibody

Product Synonym Names
RHOGAP2; Rho GTPase-activating protein 22; Rho-type GTPase-activating protein 22
Antibody/Peptide Pairs
ARHGAP22 peptide (MBS823957) is used for blocking the activity of ARHGAP22 antibody (MBS821095)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
610585
3D Structure
ModBase 3D Structure for Q7Z5H3
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes endogenous levels of ARHGAP22 protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human ARHGAP22. The exact sequence is proprietary.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-ARHGAP22 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ARHGAP22 antibody
Rabbit polyclonal antibody to ARHGAP22
Applications Tested/Suitable for anti-ARHGAP22 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ARHGAP22 antibody
WB (1/500 - 1/1000), IH (1/100 - 1/200)

Western Blot (WB) of anti-ARHGAP22 antibody
anti-ARHGAP22 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-ARHGAP22 antibody
Immunohistochemical analysis of ARHGAP22 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
anti-ARHGAP22 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for ARHGAP22. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
77,457 Da
NCBI Official Full Name
rho GTPase-activating protein 22 isoform 1
NCBI Official Synonym Full Names
Rho GTPase activating protein 22
NCBI Official Symbol
ARHGAP22  [Similar Products]
NCBI Official Synonym Symbols
RhoGAP2; RhoGap22
  [Similar Products]
NCBI Protein Information
rho GTPase-activating protein 22; rho-type GTPase-activating protein 22
UniProt Protein Name
Rho GTPase-activating protein 22
UniProt Synonym Protein Names
Rho-type GTPase-activating protein 22
UniProt Gene Name
ARHGAP22  [Similar Products]
UniProt Synonym Gene Names
RHOGAP2  [Similar Products]
UniProt Entry Name
RHG22_HUMAN
NCBI Summary for ARHGAP22
This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
UniProt Comments for ARHGAP22
ARHGAP22: Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs, Rac/Rho; GAPs

Chromosomal Location of Human Ortholog: 10q11.22

Cellular Component: focal adhesion; nucleus; cytosol

Molecular Function: protein binding; GTPase activator activity

Biological Process: regulation of small GTPase mediated signal transduction; transcription, DNA-dependent; regulation of transcription, DNA-dependent; small GTPase mediated signal transduction; angiogenesis; cell differentiation; positive regulation of GTPase activity
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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