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anti-ARHGEF1 antibody :: Rabbit ARHGEF1 Polyclonal Antibody

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Catalog # MBS2529515
Unit / Price
Scan QR to view Datasheet
  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Product Name

ARHGEF1, Polyclonal Antibody

Full Product Name

ARHGEF1 Polyclonal Antibody

Product Synonym Names
LSC; GEF1; LBCL2; SUB1.5; P115-RHOGEF
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
601855
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
2.5mg/mL (lot specific)
Immunogen
Recombinant protein of human ARHGEF1
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-ARHGEF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ARHGEF1 antibody
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.
Applications Tested/Suitable for anti-ARHGEF1 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-ARHGEF1 antibody
IHC: 1:100-1:300

Immunohistochemistry (IHC) of anti-ARHGEF1 antibody
Immunohistochemistry of paraffin-embedded Human colon cancer tissue using ARHGEF1 Polyclonal Antibody at dilution 1:60
anti-ARHGEF1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-ARHGEF1 antibody
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using ARHGEF1 Polyclonal Antibody at dilution 1:60
anti-ARHGEF1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for ARHGEF1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
105,854 Da
NCBI Official Full Name
ARHGEF1 protein
NCBI Official Synonym Full Names
Rho guanine nucleotide exchange factor (GEF) 1
NCBI Official Symbol
ARHGEF1  [Similar Products]
NCBI Official Synonym Symbols
LSC; GEF1; LBCL2; SUB1.5; P115-RHOGEF
  [Similar Products]
NCBI Protein Information
rho guanine nucleotide exchange factor 1; 115 kDa guanine nucleotide exchange factor; 115-kD protein; Lsc homolog; p115RhoGEF
UniProt Protein Name
Rho guanine nucleotide exchange factor 1
UniProt Synonym Protein Names
115 kDa guanine nucleotide exchange factor; p115-RhoGEF; p115RhoGEF; Sub1.5
UniProt Gene Name
ARHGEF1  [Similar Products]
UniProt Synonym Gene Names
p115-RhoGEF; p115RhoGEF  [Similar Products]
UniProt Entry Name
ARHG1_HUMAN
NCBI Summary for ARHGEF1
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
UniProt Comments for ARHGEF1
ARHGEF1: Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2- induced RhoA activation. Interacts with RHOA, GNA12 and GNA13. Homooligomerizes through the coiled coil region. May interact with CCPG1. Interacts with CTNNAL1. Ubiquitously expressed. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs, Rac/Rho; Motility/polarity/chemotaxis; GEFs

Chromosomal Location of Human Ortholog: 19q13.13

Cellular Component: cytoplasm; plasma membrane; cytosol

Molecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; GTPase activator activity

Biological Process: cell proliferation; nerve growth factor receptor signaling pathway; negative regulation of axonogenesis; regulation of axonogenesis; Rho protein signal transduction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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