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anti-ARL6 antibody :: Rabbit ARL6 Polyclonal Antibody

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Catalog # MBS9127886
Unit / Price
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  0.05 mL  /  $200 +1 FREE 8GB USB
  0.1 mL  /  $275 +1 FREE 8GB USB
  0.2 mL  /  $430 +1 FREE 8GB USB
Product Name

ARL6, Polyclonal Antibody

Popular Item
Full Product Name

ARL6 Polyclonal Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
600151
3D Structure
ModBase 3D Structure for Q9H0F7
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Immunogen
Recombinant Protein
Immunogen
Recombinant protein of human ARL6
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Other Notes
Small volumes of anti-ARL6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ARL6 antibody
The protein encoded by this gene belongs to the ARF-like (ADP ribosylation factor-like) sub-family of the ARF family of GTP-binding proteins which are involved in regulation of intracellular traffic. Mutations in this gene are associated with Bardet-Biedl syndrome (BBS). Alternative splicing results in multiple transcript variants of this gene. A vision-specific transcript encoding a different protein has been described (PMID: 20333246).
Applications Tested/Suitable for anti-ARL6 antibody
Western Blot (WB)
Application Notes for anti-ARL6 antibody
WB 1:500 - 1:2000

Western Blot (WB) of anti-ARL6 antibody
Western blot analysis of extracts of various cell lines, using ARL6 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
anti-ARL6 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-ARL6 antibody
Immunohistochemistry of paraffin-embedded human prostate using ARL6 antibody at dilution of 1:100 (40x lens).
anti-ARL6 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-ARL6 antibody
Immunohistochemistry of paraffin-embedded human colon using ARL6 antibody at dilution of 1:100 (40x lens).
anti-ARL6 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-ARL6 antibody
Immunohistochemistry of paraffin-embedded human liver injury using ARL6 antibody at dilution of 1:100 (40x lens).
anti-ARL6 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-ARL6 antibody
Immunohistochemistry of paraffin-embedded mouse brain using ARL6 antibody at dilution of 1:100 (40x lens).
anti-ARL6 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for ARL6. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21kDa
NCBI Official Full Name
ADP-ribosylation factor-like protein 6
NCBI Official Synonym Full Names
ADP-ribosylation factor-like 6
NCBI Official Symbol
NCBI Official Synonym Symbols
BBS3; RP55
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NCBI Protein Information
ADP-ribosylation factor-like protein 6
UniProt Protein Name
ADP-ribosylation factor-like protein 6
UniProt Synonym Protein Names
Bardet-Biedl syndrome 3 protein
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
ARL6_HUMAN
NCBI Summary for ARL6
The protein encoded by this gene belongs to the ARF-like (ADP ribosylation factor-like) sub-family of the ARF family of GTP-binding proteins which are involved in regulation of intracellular traffic. Mutations in this gene are associated with Bardet-Biedl syndrome (BBS). Alternative splicing results in multiple transcript variants of this gene. A vision-specific transcript encoding a different protein has been described (PMID: 20333246). [provided by RefSeq, May 2013]
UniProt Comments for ARL6
ARL6: Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization. Defects in ARL6 are a cause of Bardet-Biedl syndrome type 3 (BBS3). Bardet-Biedl syndrome (BBS) is a genetically heterogeneous disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Defects in ARL6 are the cause of retinitis pigmentosa type 55 (RP55). RP55 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Belongs to the small GTPase superfamily. Arf family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein, monomeric; G protein; G protein, monomeric, ARF

Chromosomal Location of Human Ortholog: 3q11.2

Cellular Component: membrane coat; membrane; cytoplasm; plasma membrane; axoneme; cytosol; cilium

Molecular Function: protein binding; GTP binding; metal ion binding; phospholipid binding

Biological Process: protein polymerization; fat cell differentiation; Wnt receptor signaling pathway; organelle organization and biogenesis; melanosome transport; visual perception; small GTPase mediated signal transduction; cilium biogenesis; brain development; determination of left/right symmetry; protein targeting to membrane; intermembrane transport; regulation of smoothened signaling pathway

Disease: Retinitis Pigmentosa 55; Bardet-biedl Syndrome 3; Bardet-biedl Syndrome 1; Retinitis Pigmentosa
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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