• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-ATF2 antibody :: Rabbit ATF2 Polyclonal Antibody

Scan QR to view Datasheet
Catalog # MBS241135
Unit / Price
Scan QR to view Datasheet
  0.05 mg  /  $530 +1 FREE 8GB USB
Product Name

ATF2, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal (IgG) to Human ATF2

Product Synonym Names
Anti-ATF2 Antibody (Ser62) IHC-plus; ATF2; CREB-2; CRE-BP1; CREB2; HB16; TREB7; CREBP1; Human ATF2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
123811
3D Structure
ModBase 3D Structure for P15336
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
Amino acids surrounding Serine 62 of human ATF2
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.02% sodium azide, 50% glycerol.
Target Species
Human
Immunogen Description
Synthetic peptide from human ATF2.
Immunogen Type
Synthetic peptide
Immunogen
ATF2 antibody was raised against synthetic peptide from human ATF2.
Antigen Modification
Ser62
Preparation and Storage
Long term: -70 degree C; Short term: -20 degree C
Other Notes
Small volumes of anti-ATF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-ATF2 antibody
Applications Tested/Suitable for anti-ATF2 antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-ATF2 antibody
IF, IHC-P (10 ug/ml), WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-ATF2 antibody
Anti-ATF2 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-ATF2 antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-ATF2 antibody
Immunofluorescence staining of methanol-fixed HeLa cells using ATF2(Ab-62 or 44) antibody.
anti-ATF2 antibody Immunofluorescence (IF) image
Western Blot (WB) of anti-ATF2 antibody
Western blot of extracts from 293 and 3T3 cells using ATF2(Ab-62 or 44) antibody.
anti-ATF2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ATF2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
15,409 Da
NCBI Official Full Name
cyclic AMP-dependent transcription factor ATF-2 isoform 1
NCBI Official Synonym Full Names
activating transcription factor 2
NCBI Official Symbol
NCBI Official Synonym Symbols
HB16; CREB2; TREB7; CREB-2; CRE-BP1
  [Similar Products]
NCBI Protein Information
cyclic AMP-dependent transcription factor ATF-2; histone acetyltransferase ATF2; cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding protein 2; cAMP response element-binding protein CRE-BP1; cyclic AMP-responsive element-binding protein 2; cAMP responsive element binding protein 2, formerly; activating transcription factor 2 splice variant ATF2-var2
UniProt Protein Name
Cyclic AMP-dependent transcription factor ATF-2
UniProt Synonym Protein Names
Activating transcription factor 2; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding protein 2; HB16; Histone acetyltransferase ATF2; cAMP response element-binding protein CRE-BP1
UniProt Gene Name
UniProt Synonym Gene Names
CREB2; CREBP1; cAMP-dependent transcription factor ATF-2; CREB-2; cAMP-responsive element-binding protein 2  [Similar Products]
UniProt Entry Name
ATF2_HUMAN
NCBI Summary for ATF2
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]
UniProt Comments for ATF2
ATF-2: a transcription factor that is a member of the leucine zipper family. Binds to the cAMP-responsive element (CRE). Forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. Also possesses histone acetyltransferase (HAT) activity that specifically acetylates histones H2B and H4 in vitro.

Protein type: Transcription factor; C2H2-type zinc finger protein; EC 2.3.1.48

Chromosomal Location of Human Ortholog: 2q32

Cellular Component: nucleoplasm; mitochondrial outer membrane; cytoplasm; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; histone acetyltransferase activity; protein heterodimerization activity; metal ion binding; transcription coactivator activity; cAMP response element binding protein binding; chromatin binding; protein kinase binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; fat cell differentiation; establishment and/or maintenance of chromatin architecture; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; positive regulation of transforming growth factor-beta2 production; response to osmotic stress; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 5 signaling pathway; regulation of transcription from RNA polymerase II promoter; MyD88-dependent toll-like receptor signaling pathway; regulation of transcription factor activity; regulation of transcription, DNA-dependent; intra-S DNA damage checkpoint; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; toll-like receptor 9 signaling pathway; histone acetylation; toll-like receptor 4 signaling pathway; response to DNA damage stimulus
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000