AAH07309.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,501 Da
NCBI Official Full Name
ATP6V1B2 protein, partial
NCBI Official Synonym Full Names
ATPase H+ transporting V1 subunit B2
NCBI Official Synonym Symbols
DOOD; HO57; VATB; VPP3; Vma2; ZLS2; ATP6B2; ATP6B1B2 [Similar Products]
NCBI Protein Information
V-type proton ATPase subunit B, brain isoform
UniProt Protein Name
V-type proton ATPase subunit B, brain isoform
UniProt Synonym Protein Names
Endomembrane proton pump 58 kDa subunit; HO57; Vacuolar proton pump subunit B 2
UniProt Synonym Gene Names
UniProt Entry Name
VATB2_HUMAN
NCBI Summary for ATP6V1B2
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq, Jul 2008]
UniProt Comments for ATP6V1B2
ATP6V1B2: Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the ATPase alpha/beta chains family.
Protein type: Hydrolase; Energy Metabolism - oxidative phosphorylation; EC 3.6.3.14
Chromosomal Location of Human Ortholog: 8p21.3
Cellular Component: cytosol; endomembrane system; integral to membrane; intracellular membrane-bound organelle; lysosomal membrane; melanosome; microvillus; myelin sheath; plasma membrane; ruffle
Molecular Function: ATP binding; hydrogen ion transmembrane transporter activity; hydrogen ion transporting ATPase activity, rotational mechanism; protein binding
Biological Process: ATP hydrolysis coupled proton transport; ATP metabolic process; insulin receptor signaling pathway; proton transport; regulation of macroautophagy; transferrin transport
Disease: Zimmermann-laband Syndrome 2
Research Articles on ATP6V1B2
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Pathways associated with anti-ATP6V1B2 antibody
Diseases associated with anti-ATP6V1B2 antibody
Organs/Tissues associated with anti-ATP6V1B2 antibody
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