NP_001015878.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,672 Da
NCBI Official Full Name
aurora kinase C isoform 1
NCBI Official Synonym Full Names
aurora kinase C
NCBI Official Synonym Symbols
AIE2; AIK3; ARK3; AurC; SPGF5; STK13; HEL-S-90; aurora-C [Similar Products]
NCBI Protein Information
aurora kinase C
UniProt Protein Name
Aurora kinase C
UniProt Synonym Protein Names
Aurora 3; Aurora/IPL1-related kinase 3; ARK-3; Aurora-related kinase 3; Aurora/IPL1/Eg2 protein 2; Serine/threonine-protein kinase 13; Serine/threonine-protein kinase aurora-C
UniProt Synonym Gene Names
AIE2; AIK3; AIRK3; ARK3; STK13; ARK-3; Aurora-related kinase 3 [Similar Products]
UniProt Entry Name
AURKC_HUMAN
NCBI Summary for AurB/C
This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
UniProt Comments for AurB/C
AurC: a member of the AUR family of kinases. May play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. Localized to centrosome from anaphase to cytokinesis. Two splice-variant isoforms have been described.
Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Kinase, protein; EC 2.7.11.1; Other group; AUR family
Chromosomal Location of Human Ortholog: 19q13.43
Cellular Component: spindle microtubule; cytoplasm; condensed chromosome; spindle; spindle midzone; midbody; spindle pole centrosome; condensed nuclear chromosome, pericentric region
Molecular Function: protein serine/threonine/tyrosine kinase activity; histone serine kinase activity; ATP binding; protein kinase activity
Biological Process: positive regulation of cytokinesis; spindle midzone assembly involved in mitosis; meiotic cell cycle; histone modification; regulation of signal transduction; cytokinesis; attachment of spindle microtubules to kinetochore; protein amino acid phosphorylation
Disease: Spermatogenic Failure 5
Research Articles on AurB/C
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Pathways associated with anti-AurB/C antibody
Diseases associated with anti-AurB/C antibody
Disease Name |
Pubmed Publications |
Infertility, Male Antibodies |
>14 publications with AurB/C and Infertility, Male |
Cell Transformation, Neoplastic Antibodies |
>8 publications with AurB/C and Cell Transformation, Neoplastic |
Abnormalities, Multiple Antibodies |
>3 publications with AurB/C and Abnormalities, Multiple |
Infertility, Female Antibodies |
>3 publications with AurB/C and Infertility, Female |
Necrosis Antibodies |
>2 publications with AurB/C and Necrosis |
Neoplasms, Experimental Antibodies |
>2 publications with AurB/C and Neoplasms, Experimental |
Intestinal Neoplasms Antibodies |
>1 publications with AurB/C and Intestinal Neoplasms |
Kidney Diseases Antibodies |
>1 publications with AurB/C and Kidney Diseases |
Weight Loss Antibodies |
>1 publications with AurB/C and Weight Loss |
Inflammation Antibodies |
>1 publications with AurB/C and Inflammation |
Organs/Tissues associated with anti-AurB/C antibody
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