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anti-AXL antibody :: Rabbit AXL Polyclonal Antibody

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Catalog # MBS9503240
Unit / Price
  0.05 mg  /  $225 +1 FREE 8GB USB
  0.1 mg  /  $310 +1 FREE 8GB USB
Product Name

AXL, Polyclonal Antibody

Popular Item
Also Known As

AXL (Phospho-Tyr691) Antibody

Product Synonym Names
Adhesion-related kinase; ARK; AXL oncogene; kinase AXL; Tyrosine-protein kinase receptor UFO precursor; UFO
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
885
OMIM
M76125 mRNA
3D Structure
ModBase 3D Structure for P30530
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
AXL (Phospho-Tyr691) Antibody detects endogenous levels of AXL only when phosphorylated at Tyr691.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho peptide.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Phospho
Modification Sites
H:Y691; M:Y692; R:Y692
Immunogen
The antiserum was produced against synthesized peptide derived from human AXL around the phosphorylation site of Tyr691.
Immunogen Range
657-706
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-AXL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-AXL antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-AXL antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:20000

Immunohistochemistry (IHC) of anti-AXL antibody
Immunohistochemistry analysis of paraffin-embedded human brain, using AXL (Phospho-Tyr691) Antibody. The picture on the right is blocked with the phospho peptide.
anti-AXL antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-AXL antibody
Western blot analysis of lysates from HUVEC cells treated with EGF 200ng/ml 15', using AXL (Phospho-Tyr691) Antibody. The lane on the right is blocked with the phospho peptide.
anti-AXL antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for AXL. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
97 kDa
NCBI Official Full Name
tyrosine-protein kinase receptor UFO isoform 2
NCBI Official Synonym Full Names
AXL receptor tyrosine kinase
NCBI Official Symbol
NCBI Official Synonym Symbols
ARK; UFO; JTK11; Tyro7
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NCBI Protein Information
tyrosine-protein kinase receptor UFO
UniProt Protein Name
Tyrosine-protein kinase receptor UFO
UniProt Synonym Protein Names
AXL oncogene
UniProt Gene Name
UniProt Synonym Gene Names
NCBI Summary for AXL
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
UniProt Comments for AXL
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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