View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List Rabbit b-Amyloid Precursor Protein Polyclonal Antibody Catalog # MBS616502 Unit / Price 0.1 mg / $880 +1 FREE 8GB USB 5x0.1 mg / $3,790 +4 FREE 8GB USB Previous Next Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name b-Amyloid Precursor Protein, Polyclonal Antibody Full Product Name b-Amyloid Precursor Protein, CT (APP) Product Synonym Names Anti -b-Amyloid Precursor Protein, CT (APP) Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Clonality Polyclonal Isotype IgG Host Rabbit Species Reactivity Human, Mouse, Rat Specificity Detects a ~105kD protein doublet, corresponding to the apparent molecular mass of APP isoforms on SDS-PAGE immunoblots, in samples from human, mouse and rat. An additional band of 35kD, corresponding to the apparent molecular mass of the C99 fragment, is also detected. Species Reactivity: human, mouse and rat Purity/Purification SerumSerum Form/Format Supplied as a liquid in PBS, 0.02% sodium azide. Immunogen Human APP synthetic peptide corresponding to residues 756-770 of the full length protein or to residues 85-99 in the human C99 fragment generated by beta-secretase cleavage. This sequence is identical in mouse and rat over these residues. Positive Control Mouse Brain Tissue Extract Preparation and Storage May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Other Notes Small volumes of anti-b-Amyloid Precursor Protein antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-b-Amyloid Precursor Protein antibody Deposition of Amyloid A4 protein precursor (APP) intraneuronally as neurofibrillary tangles, extracellularly as plaques, and in blood vessels is characteristic of both Alzheimerís disease (AD) and aged Downís Syndrome (1). The major protein found in these deposits is a small, insoluble, and highly aggregating polypeptide called amyloid beta peptide (Abeta) that is thought to be derived from aberrant catabolism of its precursor (1). Accumulation of Abeta in the cerebral cortex is a critical event in the pathogenesis of AD (2). APP is cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99 amino acid carboxy fragment (C99) (2). The C99 fragment serves as a substrate for an unknown gamma-secretase to generate the 4kD (approximately 40-42 amino acids) Abeta which forms the plaque core in AD (3). There are five forms of APP found; APP395, APP563, APP695, APP751, and APP770. They are produced by alternative splicing of the APP gene. APP695 is the most predominant form in neuronal tissue while APP751 is the predominant form found elsewhere. Product Categories/Family for anti-b-Amyloid Precursor Protein antibody Antibodies; Abs to Amyloid Applications Tested/Suitable for anti-b-Amyloid Precursor Protein antibody Western Blot (WB) Application Notes for anti-b-Amyloid Precursor Protein antibody Western Blot (ECL): 1ug/ml, Optimal dilutions to be determined by the researcher. Western Blot (WB) of anti-b-Amyloid Precursor Protein antibody Western blot analysis of APP in mouse (M) and rat (R) brain tissue lysates with MBS616502 at 2ug/ml. Immunohistochemistry (IHC) of anti-b-Amyloid Precursor Protein antibody Immunohistochemistry analysis of rat brain using MBS616502 at 2ug/ml. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP