View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List anti-braf antibody :: Rabbit B-Raf Kinase Polyclonal Antibody Catalog # MBS612626 Unit / Price 0.1 mg / $605 +1 FREE 8GB USB 5x0.1 mg / $2,555 +3 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name B-Raf Kinase (braf), Polyclonal Antibody Full Product Name B-Raf Kinase (BRAF, Ras effector) Product Synonym Names Anti -B-Raf Kinase (BRAF, Ras effector) Product Gene Name anti-braf antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Clonality Polyclonal Isotype IgG Host Rabbit Species Reactivity Human, Mouse, Rat Specificity Recognizes full length recombinant human BRaf (plus 6His tag, Mr ~94kD) and B-Raf splice variants in cell lysates (Mr ~68-94kD). Species Crossreactivity: Rat and mouse. Purity/Purification Affinity PurifiedPurified by Protein A affinity chromatography. Form/Format Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.05% sodium azide, 30% glycerol. Immunogen Synthetic peptide corresponding to aa754-765, IQAGGYGAFPVH of human B-Raf, with an N-terminal cysteine added for conjugation to KLH. Preparation and Storage May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Other Notes Small volumes of anti-braf antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-braf antibody Mutations of the BRAF gene implicated in human cancer. Cancers arise owing to the accumulation of mutations in critical genes that alter normal programmes of cell proliferation, differentiation and death. As the first stage of a systematic genome-wide screen for these genes, Davies et al. (2002, UI:22082291) have prioritized for analysis signaling pathways in which at least one gene is mutated in human cancer. The RAS (CG:176)-RAF (CG:93)-MEK (CG:1316)-ERK (CG:412)-MAP kinase pathway mediates cellular responses to growth signals. Ras is mutated to an oncogenic form in about 15% of human cancer. The three Raf genes code for cytoplasmic serine/threonine kinases that are regulated by binding RAS. Product Categories/Family for anti-braf antibody Antibodies; Abs to Protein Kinases Applications Tested/Suitable for anti-braf antibody Western Blot (WB) Application Notes for anti-braf antibody Suitable for use in Western Blot, MAP Kinase Activation and MBP Phosphorylation assays.Dilution: Western Blot: 1-2ug/ml detects B-Raf splice variants in RIPA lysates from PC12 cells and the full length purified B-Raf, active enzyme.MAP Kinase Activation and MBP Phosphorylation: 4ug TOP NCBI/Uniprot data below describe general gene information for braf. It may not necessarily be applicable to this product. NCBI GI # 148236905 NCBI GeneID 398973 NCBI Accession # NP_001083526.1 [Other Products] NCBI GenBank Nucleotide # NM_001090057.1 [Other Products] TOP NCBI Official Full Name B-Raf NCBI Official Synonym Full Names v-raf murine sarcoma viral oncogene homolog B1 NCBI Official Symbol braf [Similar Products] NCBI Official Synonym Symbols B-Raf; braf1; rafb1; b-raf1 [Similar Products] NCBI Protein Information B-Raf; serine/threonine protein kinase BRAF Protein Family Serine/threonine-protein kinase TOP Research Articles on braf 1. BRAF alternative splicing is differentially regulated in vertebrates. Exon 9b is present in all vertebrates, including Xenopus, but exon 8b is present only in eutherians. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Pathways associated with anti-braf antibody Products by Pathway Pathway Diagram ErbB Signaling Pathway antibodies ErbB Signaling Pathway Diagram ErbB Signaling Pathway antibodies ErbB Signaling Pathway Diagram Focal Adhesion Pathway antibodies Focal Adhesion Pathway Diagram Focal Adhesion Pathway antibodies Focal Adhesion Pathway Diagram Insulin Signaling Pathway antibodies Insulin Signaling Pathway Diagram Insulin Signaling Pathway antibodies Insulin Signaling Pathway Diagram MAPK Signaling Pathway antibodies MAPK Signaling Pathway Diagram MAPK Signaling Pathway antibodies MAPK Signaling Pathway Diagram Natural Killer Cell Mediated Cytotoxicity Pathway antibodies Natural Killer Cell Mediated Cytotoxicity Pathway Diagram Natural Killer Cell Mediated Cytotoxicity Pathway antibodies Natural Killer Cell Mediated Cytotoxicity Pathway Diagram Organs/Tissues associated with anti-braf antibody Organ/Tissue Name Pubmed Publications Bone Antibodies >13 publications with braf and Bone Connective Tissue Antibodies >4 publications with braf and Connective Tissue Heart Antibodies >3 publications with braf and Heart Muscle Antibodies >3 publications with braf and Muscle Brain Antibodies >3 publications with braf and Brain Vascular Antibodies >2 publications with braf and Vascular Embryonic Tissue Antibodies >2 publications with braf and Embryonic Tissue Ear Antibodies >1 publications with braf and Ear Kidney Antibodies >1 publications with braf and Kidney Umbilical Cord Antibodies >1 publications with braf and Umbilical Cord TOP © 2006-24 MyBioSource.com. 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