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anti-BACE2 A/C antibody :: Rabbit BACE2 A/C Polyclonal Antibody

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Catalog # MBS540534
Unit / Price
  0.1 mg Affinity-Purified  /  $390 +1 FREE 8GB USB
anti-BACE2 A/C antibody
Product Name

BACE2 A/C, Polyclonal Antibody

Also Known As

BACE2 A/C Antibody

Product Synonym Names
ALP 56; ASP1; ASP21; Aspartic Like Protease 56kDa; Downs Syndrome Region Aspartic Protease; DRAP; Memapsin-1; Membrane associated aspartic protease 1; Theta-secretase antibody
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
518
OMIM
605668
3D Structure
ModBase 3D Structure for Q9Y5Z0
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Predicted: Mouse, Rat
Form/Format
Affinity Purified
Concentration
0.72-0.76 ug/ul in antibody stabilization buffer (lot specific)
Immunogen
Synthetic peptide taken within amino acid region 490-518 on human BACE2 protein.
Expression
Neurons within the hippocampus, frontal cortex and temporal cortex. Lower expression in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Also found in spinal cord, medulla oblongata, substania nigra and locus coruleus. Expressed in ductal epithelium of prostate.
Molecular Function
Aspartic-type endopeptidase activity.
Structure
Belongs to the peptidase A1 family.
Subcellular Location
Endoplasmic Reticulum, Endosome, Golgi apparatus; Membrane
Preparation and Storage
-20 degree C for long term storage
Other Notes
Small volumes of anti-BACE2 A/C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BACE2 A/C antibody
Affinity Purified Beta Secretase beta-site APP cleaving Enzyme 2A/C Antibody
Responsible for the proteolytic processing of the amyloid precursor protein. Cleaves APP between 690 and 691 leading to the generation and extracellular release of beta-cleaved soluble APP and C-terminal fragment which is later released by gamma-secretase.
Applications Tested/Suitable for anti-BACE2 A/C antibody
ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-BACE2 A/C antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Western Blot: 1:500
NCBI/Uniprot data below describe general gene information for BACE2 A/C. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,476 Da
NCBI Official Full Name
BACE2
NCBI Official Synonym Full Names
beta-site APP-cleaving enzyme 2
NCBI Official Symbol
BACE2  [Similar Products]
NCBI Official Synonym Symbols
ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1
  [Similar Products]
NCBI Protein Information
beta-secretase 2
UniProt Protein Name
Beta-secretase 2
UniProt Synonym Protein Names
Aspartic-like protease 56 kDa; Aspartyl protease 1; ASP1; Asp 1; Beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; Down region aspartic protease; DRAP; Memapsin-1; Membrane-associated aspartic protease 1; Theta-secretase
UniProt Gene Name
BACE2  [Similar Products]
UniProt Synonym Gene Names
AEPLC; ALP56; ASP21; ASP1; Asp 1; Beta-site APP cleaving enzyme 2; DRAP  [Similar Products]
UniProt Entry Name
BACE2_HUMAN
NCBI Summary for BACE2 A/C
This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Comments for BACE2 A/C
BACE2: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Belongs to the peptidase A1 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.23.45; Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: cell surface; endoplasmic reticulum; endosome; Golgi apparatus; integral to membrane

Molecular Function: aspartic-type endopeptidase activity; beta-amyloid binding

Biological Process: beta-amyloid metabolic process; membrane protein ectodomain proteolysis; negative regulation of amyloid precursor protein biosynthetic process; peptide hormone processing; protein catabolic process; proteolysis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-BACE2 A/C antibody
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