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anti-BAIAP2 antibody :: Goat BAIAP2 Polyclonal Antibody

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Catalog # MBS420438
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
Western Blot (WB)
Product Name

BAIAP2, Polyclonal Antibody

Also Known As

Goat anti-BAIAP2 (isoform 1) Antibody

Product Synonym Names
Goat Anti-BAIAP2 (isoform 3) Antibody; BAIAP2; BAI1-associated protein 2; BAP2; IRSP53; FLAF3; brain-specific angiogenesis inhibitor 1-associated protein 2; fas ligand-associated factor 3; insulin receptor substrate p53; insulin receptor substrate p53/p58; BAIAP2 antibody; BAI1-associated protein 2 antibody; BAP2 antibody; IRSP53 antibody; FLAF3 antibody; brain-specific angiogenesis inhibitor 1-associated protein 2 antibody; fas ligand-associated factor 3 antibody; insulin receptor substrate p53 antibody; insulin receptor substrate p53/p58 antibody; BAIAP2 (isoform 1)
Antibody/Peptide Pairs
BAIAP2 peptide (MBS425462) is used for blocking the activity of BAIAP2 antibody (MBS420438)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
521
Immunogen Sequence
SGSGTLVSTV
OMIM
605475
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-SGSGTLVSTV, from the C Terminus of the protein sequence according to NP_059344.1.
Epitope
C Terminus
Note
This antibody is expected to recognise only human isoform 1 according to NP_059344.1.
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-BAIAP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-BAIAP2 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-BAIAP2 antibody
Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Approx 60kDa band observed in Human Brain lysates (calculated MW of 57.4kDa according to NP_059344.1). Recommended for use at 1-3ug/ml.

Western Blot (WB) of anti-BAIAP2 antibody
Staining (1ug/ml) of Human Brain lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
anti-BAIAP2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for BAIAP2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,430 Da
NCBI Official Full Name
brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 1
NCBI Official Synonym Full Names
BAI1 associated protein 2
NCBI Official Symbol
BAIAP2  [Similar Products]
NCBI Official Synonym Symbols
BAP2; FLAF3; IRSP53
  [Similar Products]
NCBI Protein Information
brain-specific angiogenesis inhibitor 1-associated protein 2
UniProt Protein Name
Brain-specific angiogenesis inhibitor 1-associated protein 2
UniProt Synonym Protein Names
Fas ligand-associated factor 3; FLAF3; Insulin receptor substrate p53/p58; IRS-58; IRSp53/58; Insulin receptor substrate protein of 53 kDa; IRSp53; Insulin receptor substrate p53
UniProt Gene Name
BAIAP2  [Similar Products]
UniProt Synonym Gene Names
BAI-associated protein 2; BAI1-associated protein 2; Protein BAP2; FLAF3; IRS-58; IRSp53/58; IRSp53; Insulin receptor substrate p53  [Similar Products]
UniProt Entry Name
BAIP2_HUMAN
NCBI Summary for BAIAP2
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
UniProt Comments for BAIAP2
IRSp53: Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Homodimer. Interacts with CDC42 and RAC1 that have been activated by GTP binding. Interacts with ATN1, BAI1, EPS8, SHANK1, SHANK2, SHANK3, WASF1 and WASF2. Interacts with ENAH after recruitment of CDC42. Interacts with TIAM1 and DIAPH1. Interacts (via SH3 domain) with E.coli effector protein EspF(U) (via PXXP motifs). Interacts with E.coli intimin receptor Tir. Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: actin cytoskeleton; cell-cell adherens junction; cytoplasm; cytosol; plasma membrane

Molecular Function: identical protein binding; protein binding; protein C-terminus binding

Biological Process: actin crosslink formation; actin filament bundle formation; axonogenesis; insulin receptor signaling pathway; positive regulation of actin filament polymerization; regulation of actin cytoskeleton organization and biogenesis; regulation of cell shape; response to bacterium; vascular endothelial growth factor receptor signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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