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anti-BAK1 antibody :: Rabbit BAK1 Polyclonal Antibody

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Catalog # MBS2526104
Unit / Price
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  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Western Blot (WB)
Product Name

BAK1, Polyclonal Antibody

Popular Item
Full Product Name

BAK1 Polyclonal Antibody

Product Synonym Names
BAK; CDN1; BCL2L7; BAK-LIKE
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
600516
3D Structure
ModBase 3D Structure for Q16611
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
1.1mg/mL (lot specific)
Immunogen
Recombinant protein of human BAK1
Calculated Molecular Weight: 23kDa
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-BAK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BAK1 antibody
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
Product Categories/Family for anti-BAK1 antibody
Applications Tested/Suitable for anti-BAK1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-BAK1 antibody
WB: 1:500-1:2000

Western Blot (WB) of anti-BAK1 antibody
Western Blot analysis of Hela, A431, 293T and Jurkat cell using BAK1 Polyclonal Antibody at dilution of 1:550
anti-BAK1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for BAK1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,872 Da
NCBI Official Full Name
BAK1
NCBI Official Synonym Full Names
BCL2-antagonist/killer 1
NCBI Official Symbol
NCBI Official Synonym Symbols
BAK; CDN1; BCL2L7; BAK-LIKE
  [Similar Products]
NCBI Protein Information
bcl-2 homologous antagonist/killer; BCL2-like 7 protein; apoptosis regulator BAK; bcl-2-like protein 7; bcl2-L-7; pro-apoptotic protein BAK
UniProt Protein Name
Bcl-2 homologous antagonist/killer
UniProt Synonym Protein Names
Apoptosis regulator BAK; Bcl-2-like protein 7; Bcl2-L-7
UniProt Gene Name
UniProt Synonym Gene Names
BAK; BCL2L7; CDN1; Bcl2-L-7  [Similar Products]
UniProt Entry Name
BAK_HUMAN
NCBI Summary for BAK1
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]
UniProt Comments for BAK1
BAK1: In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti- apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis. Interacts with BCL2A1. Homodimer. Formation of the homodimer is zinc-dependent. Forms heterodimers with BCL2, E1B 19k protein, and BCL2L1 isoform Bcl-X(L). Interacts with myxoma virus protein M11L. Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle. Belongs to the Bcl-2 family.

Protein type: Mitochondrial; Apoptosis; Endoplasmic reticulum; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: pore complex; mitochondrial outer membrane; mitochondrion; endoplasmic reticulum; cytosol; integral to mitochondrial outer membrane

Molecular Function: identical protein binding; BH domain binding; protein binding; protein homodimerization activity; protein heterodimerization activity; heat shock protein binding; chaperone binding; metal ion binding

Biological Process: response to fungus; regulation of protein heterodimerization activity; positive regulation of proteolysis; apoptosis; regulation of cell cycle; positive regulation of apoptosis; myeloid cell homeostasis; negative regulation of peptidyl-serine phosphorylation; B cell apoptosis; response to organic cyclic substance; negative regulation of cell proliferation; B cell homeostasis; regulation of mitochondrial membrane potential; response to gamma radiation; establishment and/or maintenance of transmembrane electrochemical gradient; B cell negative selection; aging; response to drug; organ regeneration; release of cytochrome c from mitochondria; mitochondrial fusion; response to mycotoxin; regulation of protein homodimerization activity; vagina development; limb morphogenesis; endocrine pancreas development; response to UV-C; cell proliferation; endoplasmic reticulum calcium ion homeostasis; unfolded protein response, activation of signaling protein activity; response to ethanol; DNA damage response, signal transduction resulting in induction of apoptosis; response to hydrogen peroxide; reduction of endoplasmic reticulum calcium ion concentration; blood vessel remodeling; caspase activation via cytochrome c; regulation of mitochondrial membrane permeability; brain development; post-embryonic camera-type eye morphogenesis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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