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anti-BCL2L2 antibody :: Rabbit BCL2L2 Polyclonal Antibody

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Catalog # MBS2528832
Unit / Price
Scan QR to view Datasheet
  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Product Name

BCL2L2, Polyclonal Antibody

Popular Item
Full Product Name

BCL2L2 Polyclonal Antibody

Product Synonym Names
BCLW; BCL-W; PPP1R51; BCL2-L-2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
601931
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
0.5mg/mL (lot specific)
Immunogen
Recombinant protein of human BCL2L2
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-BCL2L2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BCL2L2 antibody
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene.
Product Categories/Family for anti-BCL2L2 antibody
Applications Tested/Suitable for anti-BCL2L2 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-BCL2L2 antibody
IHC: 1:15-1:50

Immunohistochemistry (IHC) of anti-BCL2L2 antibody
Immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using BCL2L2 Polyclonal Antibody at dilution 1:15
anti-BCL2L2 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-BCL2L2 antibody
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using BCL2L2 Polyclonal Antibody at dilution 1:15
anti-BCL2L2 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for BCL2L2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
37,171 Da
NCBI Official Full Name
bcl-2-like protein 2
NCBI Official Synonym Full Names
BCL2-like 2
NCBI Official Symbol
BCL2L2  [Similar Products]
NCBI Official Synonym Symbols
BCLW; BCL-W; PPP1R51; BCL2-L-2
  [Similar Products]
NCBI Protein Information
bcl-2-like protein 2; apoptosis regulator BCL-W; protein phosphatase 1, regulatory subunit 51
UniProt Protein Name
Bcl-2-like protein 2
UniProt Synonym Protein Names
Apoptosis regulator Bcl-W
Protein Family
UniProt Gene Name
BCL2L2  [Similar Products]
UniProt Synonym Gene Names
BCLW; KIAA0271; Bcl2-L-2  [Similar Products]
UniProt Entry Name
B2CL2_HUMAN
NCBI Summary for BCL2L2
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]
UniProt Comments for BCL2L2
BCL2L2: Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. Expressed in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines. Belongs to the Bcl-2 family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 14q11.2-q12

Cellular Component: mitochondrial outer membrane; cytosol

Molecular Function: BH domain binding; protein binding; protein homodimerization activity; protein heterodimerization activity

Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; spermatogenesis; Sertoli cell proliferation; negative regulation of apoptosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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