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anti-BMPR2 antibody :: Rabbit bone morphogenetic protein receptor, type II Polyclonal Antibody

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Catalog # MBS716929
Unit / Price
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  0.05 mL  /  $230 +1 FREE 8GB USB
  0.15 mL  /  $500 +1 FREE 8GB USB
anti-BMPR2 antibody
Product Name

bone morphogenetic protein receptor, type II (BMPR2), Polyclonal Antibody

Full Product Name

Rabbit anti-human bone morphogenetic protein receptor, type II (serine/threonine kinase) polyclonal Antibody

Product Synonym Names
bone morphogenetic protein receptor; type II (serine/threonine kinase); BMPR2; BMPR-II; BMPR3; BMR2; BRK-3; FLJ41585; FLJ76945; PPH1; T-ALK
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
600799
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Immunogen
Human BMPR2
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-5682 / sc-5683 / sc-20737 / sc-130704
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-BMPR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-BMPR2 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for BMPR2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,963 Da[Similar Products]
NCBI Official Full Name
Bone morphogenetic protein receptor type-2
NCBI Official Synonym Full Names
bone morphogenetic protein receptor, type II (serine/threonine kinase)
NCBI Official Symbol
BMPR2  [Similar Products]
NCBI Official Synonym Symbols
BMR2; PPH1; BMPR3; BRK-3; POVD1; T-ALK; BMPR-II
  [Similar Products]
NCBI Protein Information
bone morphogenetic protein receptor type-2; BMPR-2; BMP type-2 receptor; BMP type II receptor; type II activin receptor-like kinase; bone morphogenetic protein receptor type II; type II receptor for bone morphogenetic protein-4
UniProt Protein Name
Bone morphogenetic protein receptor type-2
UniProt Synonym Protein Names
Bone morphogenetic protein receptor type II; BMP type II receptor; BMPR-II
UniProt Gene Name
BMPR2  [Similar Products]
UniProt Synonym Gene Names
PPH1; BMP type-2 receptor; BMPR-2; BMP type II receptor; BMPR-II  [Similar Products]
UniProt Entry Name
BMPR2_HUMAN
NCBI Summary for BMPR2
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, Jul 2008]
UniProt Comments for BMPR2
BMPR2: a serine/threonine-protein kinase receptor for bone morphogenetic protein (BMP). Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Defects in BMPR2 are the cause of primary pulmonary hypertension (PPH1), a weakly penetrant dominant disorder, associated with lesions in pulmonary arterioles, elevated pulmonary arterial pressure, and right ventricular failure.

Protein type: Protein kinase, TKL; EC 2.7.11.30; Membrane protein, integral; Kinase, protein; Protein kinase, Ser/Thr (receptor); Cell cycle regulation; TKL group; STKR family; Type2 subfamily

Chromosomal Location of Human Ortholog: 2q33-q34

Cellular Component: extracellular space; cell surface; cell soma; integral to plasma membrane; cytoplasm; dendrite; apical plasma membrane; plasma membrane; basal plasma membrane; caveola

Molecular Function: transforming growth factor beta receptor activity; protein binding; metal ion binding; growth factor binding; activin receptor activity, type II; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: limb development; transcription from RNA polymerase II promoter; regulation of lung blood pressure; activin receptor signaling pathway; protein amino acid phosphorylation; BMP signaling pathway; anterior/posterior pattern formation; proteoglycan biosynthetic process; transmembrane receptor protein serine/threonine kinase signaling pathway; lymphangiogenesis; positive regulation of BMP signaling pathway; negative regulation of systemic arterial blood pressure; chondrocyte development; positive regulation of bone mineralization; cellular response to starvation; negative regulation of vasoconstriction; regulation of cell proliferation; positive regulation of osteoblast differentiation; mesoderm formation; positive regulation of axon extension involved in axon guidance; positive regulation of endothelial cell proliferation; blood vessel remodeling; negative regulation of cell growth; brain development; vascular endothelial growth factor receptor signaling pathway; alveolus development

Disease: Pulmonary Venoocclusive Disease 1, Autosomal Dominant; Pulmonary Hypertension, Primary, 1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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