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anti-IBSP antibody :: Rabbit Bone Sialoprotein Polyclonal Antibody

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Catalog # MBS175104
Unit / Price
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  0.1 mg  /  $315 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

Bone Sialoprotein (IBSP), Polyclonal Antibody

Full Product Name

Anti-Bone Sialoprotein antibody

Product Synonym Names
Bone sialoprotein 2; integrin-binding sialoprotein; BNSP antibody; Bone sialoprotein 2 antibody; Bone sialoprotein 2 precursor antibody; Bone sialoprotein II antibody; bone sialoprotein II; bone sialoprotein antibody; BSP antibody; BSP II antibody; BSPII antibody; Cell binding sialoprotein antibody; Cell-binding sialoprotein antibody; IBSP antibody; Integrin binding sialoprotein antibody; Integrin binding sialoprotein(bone sialoprotein II) antibody; integrin binding sialoprotein(bone sialoprotein, bone sialoprotein II) antibody; Integrin-binding sialoprotein antibody; SIAL_HUMAN antibody; SPII antibody
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
147563
3D Structure
ModBase 3D Structure for P21815
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Immunogen affinity purified.
Form/Format
Lyophilized
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human Bone Sialoprotein (17-34aa FSMKNLHRRVKIEDSEEN), different from the related rat and mouse sequences by three amino acids.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-IBSP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IBSP antibody
Description: Rabbit IgG polyclonal antibody for Bone sialoprotein 2(IBSP) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Background: BSP is also known as IBSP(integrin-binding sialoprotein). The protein encoded by this gene is a major structural protein of the bone matrix. Bone sialoprotein is an acidic glycoprotein of approximately 70 kD that undergoes extensive posttranslational modifications. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. The BSP gene is mapped to 4q22.1.
Applications Tested/Suitable for anti-IBSP antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Immunohistochemistry (IHC) of anti-IBSP antibody
Anti-Bone Sialoprotein antibody, MBS175104, IHC(P)
IHC(P): Human Osteosarcoma Tissue
anti-IBSP antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for IBSP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
35,148 Da
NCBI Official Full Name
Bone sialoprotein 2
NCBI Official Synonym Full Names
integrin-binding sialoprotein
NCBI Official Symbol
NCBI Official Synonym Symbols
BSP; BNSP; SP-II; BSP-II
  [Similar Products]
NCBI Protein Information
bone sialoprotein 2; BSP II; bone sialoprotein II; cell-binding sialoprotein
UniProt Protein Name
Bone sialoprotein 2
UniProt Synonym Protein Names
Bone sialoprotein II; BSP II; Cell-binding sialoprotein; Integrin-binding sialoprotein
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
BNSP; BSP II  [Similar Products]
UniProt Entry Name
SIAL_HUMAN
NCBI Summary for IBSP
The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008]
UniProt Comments for IBSP
Sialoprotein-2: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.

Protein type: Secreted, signal peptide; Secreted; Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q21.1

Cellular Component: extracellular space; membrane; extracellular region

Biological Process: osteoblast differentiation; extracellular matrix organization and biogenesis; biomineral formation; cell adhesion
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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