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anti-c-Jun antibody :: Rabbit c-Jun Polyclonal Antibody

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Catalog # MBS440024
Unit / Price
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  0.2 mg  /  $240 +1 FREE 8GB USB
Western Blot (WB)
Product Name

c-Jun, Polyclonal Antibody

Full Product Name

c-Jun (A15) Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q4ZJE9
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, rat, human
Specificity
Mouse, rat and human c-Jun p39
Form/Format
200 ug/ml rabbit polyclonal IgG in 1 ml PBS containing 0.1 % sodium azide and 0.2% gelatin.
Concentration
0.200 mg/ml (lot specific)
Origin
c-Jun (A15) is provided as an affinity purified rabbit polyclonal antibody, raised against a peptide mapping to the amino terminus of mouse c-Jun p39.
Immunogen
Synthetic peptide mapping to the amino terminus of mouse c-Jun p39.
Preparation and Storage
Store this product at 4 degree C, do not freeze. The product is stable for one year from the date of shipment.
Other Notes
Small volumes of anti-c-Jun antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-c-Jun antibody
The products of the proto-oncogenes c-Jun (c-Jun was previously known as the Fos-binding protein p39) and c-Fos are known to form a complex in the nucleus (2, 6). AP-1 (activating protein-1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF (activating transcription factor) subunits that bind to a common DNA site, the AP-1-binding site (1). There is evidence that AP-1 proteins, mostly those that belong to the Jun group, control cell life and death through their ability to regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16 (3). The Fos and Jun proto-oncogenes expression is induced transiently by a great variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons (5). Studies have established a unique role for Fos in determining the differentiation and activity of progenitors of the osteoclast lineage (4). c-Jun is a transcription factor belonging to the activator protein 1 family. A mutated version of c-Jun (v-Jun) transduced by the avian retrovirus ASV17 induces oncogenic transformation in avian cell cultures and sarcomas in young galliform birds. The oncogenicity of c-Jun probably results from transcriptional deregulation of v-Jun-responsive target genes (7).
Applications Tested/Suitable for anti-c-Jun antibody
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
Application Notes for anti-c-Jun antibody
c-Jun DB026 (A14) reacts with c-Jun p39 of mouse, rat and human origin by western blotting, immunoprecipitation and immunohistochemistry. Western blotting starting dilution: 1:200.

Western Blot (WB) of anti-c-Jun antibody
anti-c-Jun antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for c-Jun. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
Molecular Weight
33,849 Da
NCBI Official Full Name
transcription factor AP-1
NCBI Official Synonym Full Names
jun proto-oncogene
NCBI Official Symbol
NCBI Official Synonym Symbols
c-Jun; fj36h07; zgc:65863; wu:fj36h07
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NCBI Protein Information
transcription factor AP-1; v-jun sarcoma virus 17 oncogene homolog
UniProt Protein Name
C-Jun
UniProt Synonym Protein Names
C-Jun
UniProt Gene Name
UniProt Entry Name
Q4ZJE9_DANRE
Product References and Citations for anti-c-Jun antibody
1.) Himes SR, Sester DP, Ravasi T, Cronau SL, Sasmono T, Hume DA. 2006. The JNK are important for development and survival of macrophages. J Immunol. Feb 15;176(4):2219-28.2.) Dann SG, Ted Allison W, Veldhoen K, Johnson T, Hawryshyn CW. 2004. Chromatin immunoprecipitation assay on the rainbow trout opsin proximal promoters illustrates binding of NF-kappaB and c-jun to the SWS1 promoter in the retina. Exp Eye Res. May;78(5):1015-24.

1. Karin M, Liu Zg, Zandi E. AP-1 function and regulation.Curr Opin Cell Biol. 1997 Apr;9(2):240-6.2. Bos TJ, Rauscher FJ 3rd, Curran T, Vogt PK. The carboxy terminus of the viral Jun oncoprotein is required for complex formation with the cellular Fos protein. Oncogene. 1989 Feb;4(2):123-6.3. Shaulian E, Karin M. AP-1 in cell proliferation and survival. Oncogene. 2001 Apr 30;20(19):2390-400.4. Liebermann DA, Gregory B, Hoffman B. AP-1 (Fos/Jun) transcription factors in hematopoietic differentiation and apoptosis. Int J Oncol. 1998 Mar;12(3):685-7005. Curran T. Fos and Jun: oncogenic transcription factors.Tohoku J Exp Med. 1992 Oct;168(2):169-74.6. Rauscher FJ 3rd, Voulalas PJ, Franza BR Jr, Curran T. Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro. Genes Dev. 1988 Dec;2(12B):1687-99.7. Fu Sl, Bottoli I, Goller M, Vogt PK. Heparin-binding epidermal growth factor-like growth factor, a v-Jun target gene, induces oncogenic transformation.. Proc Natl Acad Sci U S A. 1999 May 11;96(10):5716-21.

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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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