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anti-c-Src antibody :: Rabbit c-Src Polyclonal Antibody

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Catalog # MBS440022
Unit / Price
  0.2 mg  /  $240 +1 FREE 8GB USB
anti-c-Src antibody
Product Name

c-Src, Polyclonal Antibody

Also Known As

c-Src (A16) Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
351
OMIM
190090
3D Structure
ModBase 3D Structure for P12931
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, rat, human
Specificity
Mouse, rat and human cSrc
Form/Format
200 ug/ml rabbit polyclonal IgG in 1 ml PBS containing 0.1 % sodium azide and 0.2% gelatin.
Concentration
0.200 mg/ml (lot specific)
Origin
c-Src (A16) is provided as an affinity purified rabbit polyclonal antibody, raised against a peptide mapping to the amino terminus of human c-Src p60.
Immunogen
Synthetic peptide mapping to the amino terminus of human c-Src p60.
Preparation and Storage
Store this product at 4 degree C, do not freeze. The product is stable for one year from the date of shipment.
Other Notes
Small volumes of anti-c-Src antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-c-Src antibody
The Src gene family is represented by at least eight different protein tyrosine kinases belonging to the non-receptor tyrosine kinases (1,2). These protein tyrosine kinases are important regulators of many cellular processes, including cytoskeletal organization, cell-cell contact, DNA synthesis, and cellular proliferation (1-3). Members of this group of proteins include c-Src, c-Yes, Fyn, Lck, Lyn, Hck, Blk and c-Fgr. The proto-oncogene c-Src is the prototype member of this gene family and is expressed in a broad range of tissues and cells (4,5). Elevated c-Src tyrosine kinase activity has been found in many types of human cancers, most notably in breast carcinomas (6,7). The activity of c-Src in these human cancers has been attributed to increases c-Src expression, elevated c-Src specific activity and activating mutations in c-Src (6,7).
Applications Tested/Suitable for anti-c-Src antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-c-Src antibody
Western blotting starting dilution: 1:200.
NCBI/Uniprot data below describe general gene information for c-Src. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,589 Da
NCBI Official Full Name
c-src, partial
NCBI Official Synonym Full Names
SRC proto-oncogene, non-receptor tyrosine kinase
NCBI Official Symbol
NCBI Official Synonym Symbols
ASV; SRC1; c-SRC; p60-Src
  [Similar Products]
NCBI Protein Information
proto-oncogene tyrosine-protein kinase Src; proto-oncogene c-Src; protooncogene SRC, Rous sarcoma; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
UniProt Protein Name
Proto-oncogene tyrosine-protein kinase Src
UniProt Synonym Protein Names
Proto-oncogene c-Src; pp60c-src; p60-Src
UniProt Gene Name
UniProt Synonym Gene Names
SRC1; p60-Src  [Similar Products]
UniProt Entry Name
SRC_HUMAN
NCBI Summary for c-Src
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for c-Src
Src: proto-oncogenic cytoplasmic tyrosine kinase of the SRC family. Highly expressed in certain fully differentiated cells such as neurons, platelets and macrophages. Phosphorylation of an activation loop tyrosine activates the enzyme; phosphorylation of a tyrosine in the C-terminus by Csk inhibits the enzyme. Two alternatively spliced isoforms have been described.

Protein type: EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Oncoprotein; Protein kinase, TK; Kinase, protein; TK group; Src family

Chromosomal Location of Human Ortholog: 20q12-q13

Cellular Component: neuron projection; mitochondrion; lysosome; postsynaptic density; actin filament; caveola; cytosol; extrinsic to internal side of plasma membrane; perinuclear region of cytoplasm; cytoplasm; late endosome; mitochondrial inner membrane; plasma membrane; nucleus

Molecular Function: protein C-terminus binding; ephrin receptor binding; non-membrane spanning protein tyrosine kinase activity; phosphoprotein binding; insulin receptor binding; protein kinase activity; integrin binding; protein binding; enzyme binding; protein kinase C binding; SH3/SH2 adaptor activity; protein-tyrosine kinase activity; heme binding; estrogen receptor binding; kinase activity; SH2 domain binding; ATP binding; hormone receptor binding; receptor binding

Biological Process: oogenesis; regulation of estrogen receptor signaling pathway; estrogen receptor signaling pathway; progesterone receptor signaling pathway; positive regulation of cyclin-dependent protein kinase activity; central nervous system development; viral reproduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; regulation of cell cycle; positive regulation of transcription, DNA-dependent; uterus development; negative regulation of mitochondrial depolarization; negative regulation of protein homooligomerization; positive regulation of MAP kinase activity; cell-cell adhesion; transforming growth factor beta receptor signaling pathway; response to electrical stimulus; cell adhesion; bone resorption; response to drug; platelet activation; fibroblast growth factor receptor signaling pathway; response to virus; activation of protein kinase B; transcytosis; positive regulation of integrin activation; positive regulation of protein amino acid autophosphorylation; cellular response to insulin stimulus; response to mechanical stimulus; T cell costimulation; regulation of vascular permeability; negative regulation of transcription, DNA-dependent; leukocyte migration; negative regulation of apoptosis; axon guidance; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; platelet-derived growth factor receptor signaling pathway; negative regulation of caspase activity; positive regulation of smooth muscle cell migration; signal transduction; regulation of cell-cell adhesion; forebrain development; ephrin receptor signaling pathway; integrin-mediated signaling pathway; response to nutrient levels; epidermal growth factor receptor signaling pathway; regulation of bone resorption; negative regulation of focal adhesion formation; signal complex assembly; positive regulation of phosphoinositide 3-kinase activity; response to mineralocorticoid stimulus; cell cycle; regulation of cell proliferation; positive regulation of protein kinase B signaling cascade; cell proliferation; peptidyl-serine phosphorylation; response to hydrogen peroxide; regulation of protein binding; Ras protein signal transduction; stress fiber formation; innate immune response; positive regulation of insulin receptor signaling pathway; response to acidity; vascular endothelial growth factor receptor signaling pathway; blood coagulation; positive regulation of cytokine secretion
Product References and Citations for anti-c-Src antibody
1.)Ardizzone TD, Zhan X, Ander BP, Sharp FR. 2007, SRC kinase inhibition improves acute outcomes after experimental intracerebral hemorrhage. Stroke. 2007 May;38(5):1621-5.

1. Oda H, Kumar S, Howley PM. 1999. Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination. Proc Natl Acad Sci USA 96(17):9557-9562. 2. Biscardi JS, Ishizawar RC, Silva CM, Parsons SJ. 2000. Tyrosine kinase signalling in breast cancer: epidermal growth factor receptor and c-Src interaction in breast cancer. Breast Cancer Res 2(3):203-210.3. Ingraham CA, Cox ME, Ward DC, Fults DW, Maness PF. 1989. c-Src and other proto-oncogenes implicated in neuronal differentiation. Mol Chem Neuropathol 10(1):1-14.4. Wiestler OD, Walter G. 1988. Developmental expression of two forms of pp60c-src in mouse brain. Mol Cell Biol 8(1):502-504.5. Yang XM, Martinez R, Le Beau J, Wiestler O, Walter G. Evolutionary expression of the neuronal form of the src protein. Proc Natl Acad Sci USA 86(12):4751-4755.6. Bjorge JD, Pang A, Fujita DJ. 2000. Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines. J Biol Chem 275(52):41439-41446.7. Hung W, Elliot B. 2001. Co-operative effect of c-Src tyrosine kinase and Stat3 in activation of hepatocyte growth factor expression in mammary carcinoma cells. J Biol Chem 276(15):12395-12403.

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