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anti-CAMLG antibody :: Rabbit Calcium Modulating Ligand Polyclonal Antibody

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Catalog # MBS2032668 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
  0.01 mg  /  $110 +1 FREE 8GB USB
  0.02 mg  /  $130 +1 FREE 8GB USB
  0.05 mg  /  $175 +1 FREE 8GB USB
  0.1 mg  /  $225 +1 FREE 8GB USB
  0.2 mg  /  $340 +1 FREE 8GB USB
  1 mg  /  $800 +1 FREE 8GB USB
Product Name

Calcium Modulating Ligand (CAMLG), Polyclonal Antibody

Popular Item
Also Known As

Calcium Modulating Ligand (CAMLG) Polyclonal Antibody

Product Synonym Names
CAML; Calcium Signal-Modulating Cyclophilin Ligand; Calcium-Signal Modulating Cyclophilin Ligand; Cyclophilin B-Binding Protein
Matching Pairs
Matching Pairs
Matching Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
296
OMIM
U18242 mRNA
3D Structure
ModBase 3D Structure for P49069
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
The antibody is a rabbit polyclonal antibody raised against CAMLG. It has been selected for its ability to recognize CAMLG in immunohistochemical staining and western blotting.
Purity/Purification
Affinity Chromatography
Form/Format
Supplied as solution form in PBS, pH7.4 containing 0.02% NaN3, 50% glycerol.
Concentration
200ug/ml (lot specific)
Immunoglobulin Type
IgG
Conjugate
No Conjugate
Organism Species
Human
Fragment
CAMLG (Gly19~Glu184)
Quality Control
Content: The quality control contains recombinant CAMLG (Gly19~Glu184) disposed in loading buffer.
Usage: 10uL per well when 3,3'-Diaminobenzidine(DAB) as the substrate.
5uL per well when used in enhanced chemilumescent (ECL).
Note: The quality control is specifically manufactured as the positive control.Not used for other purposes.
Loading Buffer: 100mM Tris(pH8.8), 2% SDS, 200mM NaCl, 50% glycerol,BPB 0.01%, NaN3 0.02%.
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2065082
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Other Notes
Small volumes of anti-CAMLG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-CAMLG antibody
Applications Tested/Suitable for anti-CAMLG antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)
Application Notes for anti-CAMLG antibody
Western Blot: 1:50-400
Immunohistochemistry in formalin fixed frozen section: 1:50-500
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-CAMLG antibody
Western Blot: Sample: Human HepG2 cell lysate; Primary Ab: 1ug/ml Rabbit Anti-Human CAMLG Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
anti-CAMLG antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-CAMLG antibody
Western Blot: Sample: Recombinant protein.
anti-CAMLG antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-CAMLG antibody
DAB staining on fromalin fixed paraffin- embedded Kidney tissue)
anti-CAMLG antibody Immunohistochemistry (IHC) (IHC) image
Knockout Validation of anti-CAMLG antibody
Knockout Validation: Lane 1: Wild-type Jurkat cell lysate; Lane 2: CAMLG knockout Jurkat cell lysate; Predicted MW: 33kd Observed MW: 37kd Primary Ab: 1ug/ml Rabbit Anti-Human CAMLG Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047)
anti-CAMLG antibody Knockout Validation image
NCBI/Uniprot data below describe general gene information for CAMLG. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
32,953 Da
NCBI Official Full Name
calcium signal-modulating cyclophilin ligand
NCBI Official Synonym Full Names
calcium modulating ligand
NCBI Official Symbol
CAMLG  [Similar Products]
NCBI Official Synonym Symbols
CAML; GET2
  [Similar Products]
NCBI Protein Information
calcium signal-modulating cyclophilin ligand
UniProt Protein Name
Calcium signal-modulating cyclophilin ligand
UniProt Gene Name
CAMLG  [Similar Products]
UniProt Synonym Gene Names
CAML; CAML  [Similar Products]
NCBI Summary for CAMLG
The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]
UniProt Comments for CAMLG
CAMLG: Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B.

Protein type: Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: endoplasmic reticulum; integral component of membrane; membrane

Molecular Function: cell adhesion molecule binding; protein binding

Biological Process: defense response; epidermal growth factor receptor signaling pathway; receptor recycling; signal transduction; viral process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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