NP_001211.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50 kD, 60 kD
NCBI Official Full Name
calcium/calmodulin-dependent protein kinase type II subunit beta isoform 1
NCBI Official Synonym Full Names
calcium/calmodulin dependent protein kinase II beta
NCBI Protein Information
calcium/calmodulin-dependent protein kinase type II subunit beta
UniProt Protein Name
Calcium/calmodulin-dependent protein kinase type II subunit beta
UniProt Synonym Gene Names
CAM2; CAMK2; CAMKB; CaM kinase II subunit beta; CaMK-II subunit beta [Similar Products]
NCBI Summary for CaMKII
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
UniProt Comments for CaMKII
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitch muscle participates in the control of Ca2+ release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
Research Articles on CaMKII
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Pathways associated with anti-CaMKII antibody
Diseases associated with anti-CaMKII antibody
Organs/Tissues associated with anti-CaMKII antibody
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