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anti-CADPS antibody :: Rabbit CAPS1 Polyclonal Antibody

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Catalog # MBS150862
Unit / Price
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  0.1 mg  /  $375 +1 FREE 8GB USB
Product Name

CAPS1 (CADPS), Polyclonal Antibody

Popular Item
Full Product Name

CAPS1 Antibody

Product Synonym Names
CAPS1; CAPS; CAPS1; CADPS1; CAPS; KIAA1121; Calcium-dependent secretion activator 1; Calcium-dependent activator protein for secretion 1; CAPS-1; Ca++-dependent secretion activator
Antibody/Peptide Pairs
CAPS1 peptide (MBS151794) is used for blocking the activity of CAPS1 antibody (MBS150862)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9ULU8
Species Reactivity
Human, Mouse, Rat
Numerous isoforms of CAPS1 are known to exist; the lower molecular weight bands seen in the immunoblot image are likely to be these isoforms. This CAPS1 antibody is predicted to be specific to CAPS1 and not recognize CAPS2.
CAPS1 Antibody is affinity chromatography purified via peptide column.
1 mg/mL (lot specific)
CAPS1 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of the human CAPS1.
CAPS1 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
CAPS1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-CADPS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CADPS antibody
CAPS1 Antibody: CAPS1 and its related protein CAPS2 encode novel neural/endocrine-specific cytosolic and peripheral membrane proteins. Both are essential components of the synaptic vesicle priming machinery and are required for the Ca2+-regulated exocytosis of secretory vesicles; CAPS-deficienct neurons contain no or very few fusion competent synaptic vesicles, causing a selective impairment of fast phasic transmitter release. CAPS1 acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4, 5-bisphosphate and is thought to be a specific regulator of large dense-core vesicle fusion.
Applications Tested/Suitable for anti-CADPS antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-CADPS antibody
CAPS1 antibody can be used for detection of CAPS1 by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-CADPS antibody
Western blot analysis of CAPS1 in rat brain tissue lysate with CAPS1 antibody at (A) 0.5 and (B) 1 μg/mL.
anti-CADPS antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-CADPS antibody
Immunohistochemistry of CAPS1 in human brain with CAPS1 antibody at 5 μg/mL.
anti-CADPS antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-CADPS antibody
Immunofluorescence of CAPS1 in human brain tissue with CAPS1 antibody at 20 μg/mL.
anti-CADPS antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for CADPS. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,236 Da
NCBI Official Full Name
calcium-dependent secretion activator 1 isoform 2
NCBI Official Synonym Full Names
Ca++-dependent secretion activator
NCBI Official Symbol
CADPS  [Similar Products]
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
calcium-dependent secretion activator 1; CAPS-1; Ca2+-dependent secretion activator; Ca2+-regulated cytoskeletal protein; Ca2+-dependent activator protein for secretion; calcium-dependent activator protein for secretion 1
UniProt Protein Name
Calcium-dependent secretion activator 1
UniProt Synonym Protein Names
Calcium-dependent activator protein for secretion 1; CAPS-1
UniProt Gene Name
CADPS  [Similar Products]
UniProt Synonym Gene Names
CAPS; CAPS1; KIAA1121; CAPS-1  [Similar Products]
UniProt Entry Name
NCBI Summary for CADPS
This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]
UniProt Comments for CADPS
CADPS: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 3p14.2

Cellular Component: cytoplasmic vesicle membrane; synapse; cytosol; cell junction

Molecular Function: protein binding; metal ion binding; lipid binding; protein kinase binding

Biological Process: catecholamine secretion; protein transport; exocytosis; vesicle organization and biogenesis; synaptic vesicle priming
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Products associated with anti-CADPS antibody
 Reference Product  PubMed Publications
 CAPS2 antibody  >11 publications with CADPS and CAPS2
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