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anti-CHST14 antibody :: Rabbit carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 Polyclonal Antibody

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Catalog # MBS714720
Unit / Price
  0.05 mL  /  $230 +1 FREE 8GB USB
  0.15 mL  /  $500 +1 FREE 8GB USB
anti-CHST14 antibody
Product Name

carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 (CHST14), Polyclonal Antibody

Also Known As

Rabbit anti-human carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 polyclonal Antibody

Product Synonym Names
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14; CHST14; D4ST-1; D4ST1; HD4ST; HNK1ST
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
376
OMIM
608429
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Immunogen
Human CHST14
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-68295 / sc-68294
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-CHST14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CHST14 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for CHST14. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,997 Da[Similar Products]
NCBI Official Full Name
Carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
NCBI Official Synonym Full Names
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
NCBI Official Symbol
CHST14  [Similar Products]
NCBI Official Synonym Symbols
ATCS; D4ST1; EDSMC1; HNK1ST
  [Similar Products]
NCBI Protein Information
carbohydrate sulfotransferase 14; dermatan 4 sulfotransferase 1
UniProt Protein Name
Carbohydrate sulfotransferase 14
UniProt Synonym Protein Names
Dermatan 4-sulfotransferase 1; D4ST-1; hD4ST1
UniProt Gene Name
CHST14  [Similar Products]
UniProt Synonym Gene Names
D4ST1; D4ST-1; hD4ST1  [Similar Products]
UniProt Entry Name
CHSTE_HUMAN
NCBI Summary for CHST14
This gene encodes a member of the HNK-1 family of sulfotransferases. The encoded protein transfers sulfate to the C-4 hydroxyl of N-acetylgalactosamine residues in dermatan sulfate. Mutations in this gene have been associated with adducted thumb-clubfoot syndrome.[provided by RefSeq, Mar 2010]
UniProt Comments for CHST14
CHST14: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. GlcUA to IdoUA. Appears to have an important role in the formation of the cerbellar neural network during postnatal brain development. Defects in CHST14 are the cause of Ehlers-Danlos syndrome musculocontractural type (EDSMC). It is a form of Ehlers-Danlos syndrome characterized by distinctive craniofacial dysmorphism, congenital contractures of thumbs and fingers, clubfeet, severe kyphoscoliosis, muscular hypotonia, hyperextensible thin skin with easy bruisability and atrophic scarring, wrinkled palms, joint hypermobility, and ocular involvement. Belongs to the sulfotransferase 2 family.

Protein type: Transferase; Glycan Metabolism - chondroitin sulfate biosynthesis; EC 2.8.2.35; Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q15.1

Cellular Component: Golgi membrane; integral to membrane

Molecular Function: N-acetylgalactosamine 4-O-sulfotransferase activity; phosphate binding

Biological Process: chondroitin sulfate metabolic process; glycosaminoglycan metabolic process; dermatan sulfate proteoglycan metabolic process; carbohydrate metabolic process; pathogenesis; carbohydrate biosynthetic process; dermatan sulfate biosynthetic process

Disease: Ehlers-danlos Syndrome, Musculocontractural Type 1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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