P55210.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31,614 Da
NCBI Official Full Name
Caspase-7
NCBI Official Synonym Full Names
caspase 7, apoptosis-related cysteine peptidase
NCBI Official Synonym Symbols
MCH3; CMH-1; LICE2; CASP-7; ICE-LAP3 [Similar Products]
NCBI Protein Information
caspase-7; apoptotic protease MCH-3; ICE-like apoptotic protease 3; caspase 7, apoptosis-related cysteine protease
UniProt Protein Name
Caspase-7
UniProt Synonym Protein Names
Apoptotic protease Mch-3; CMH-1; ICE-like apoptotic protease 3; ICE-LAP3
UniProt Synonym Gene Names
UniProt Entry Name
CASP7_HUMAN
NCBI Summary for CASP7
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
UniProt Comments for CASP7
CASP7: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly- 217' bond. Overexpression promotes programmed cell death. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain. Inhibited by isatin sulfonamides. Belongs to the peptidase C14A family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Endoplasmic reticulum; Apoptosis; Protease; Mitochondrial; EC 3.4.22.60
Chromosomal Location of Human Ortholog: 10q25
Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol
Molecular Function: protein binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity
Biological Process: apoptosis; caspase activation via cytochrome c; proteolysis; cell structure disassembly during apoptosis
Research Articles on CASP7
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Products associated with anti-CASP7 antibody
Pathways associated with anti-CASP7 antibody
Diseases associated with anti-CASP7 antibody
Organs/Tissues associated with anti-CASP7 antibody
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