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anti-CASR antibody :: Rabbit CASR Polyclonal Antibody

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Catalog # MBS153366
Unit / Price
  0.1 mg  /  $375 +1 FREE 8GB USB
Product Name

CASR, Polyclonal Antibody

Also Known As

CASR Antibody

Product Synonym Names
CASR; CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; GPRC2A; HYPOC1; Extracellular calcium-sensing receptor; Parathyroid cell calcium-sensing receptor 1; CaSR; calcium-sensing receptor
Antibody/Peptide Pairs
CASR peptide (MBS154125) is used for blocking the activity of CASR antibody (MBS153366)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1088
OMIM
gene+phenotype 612899
3D Structure
ModBase 3D Structure for P41180
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
CASR antibody is human, mouse and rat reactive. At least two isoforms of CASR are known to exist.
Purity/Purification
CASR antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (lot specific)
Conjugate
Unconjugated
Immunogen
CASR antibody was raised against a 15 amino acid peptide near the amino terminus of human CASR.
Buffer
CASR Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
CASR antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
Other Notes
Small volumes of anti-CASR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CASR antibody
The calcium-sensing receptor protein (CASR) is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule (1). It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis (1). Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism (1,2). Recent evidence suggests that activated CASR contributes to the cytokine secretion through the partial MAPK and NF-kappaB pathways in T cells (3).
Applications Tested/Suitable for anti-CASR antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-CASR antibody
CASR antibody can be used for detection of CASR by Western blot at 1 - 2 mug/ml. Antibody can also be used for Immunohistochemistry at 5 mug/mL. For Immunoflorescence start at 20 mug/mL.

Western Blot (WB) of anti-CASR antibody
Western blot analysis of CASR in EL4 cell lysate with CASR antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
anti-CASR antibody Western Blot (WB) (WB) image
Immunofluorescence (IF) of anti-CASR antibody
Immunofluorescence of CASR in human kidney tissue with CASR antibody at 20 μg/mL.
anti-CASR antibody Immunofluorescence (IF) image
Immunohistochemistry (IHC) of anti-CASR antibody
Immunohistochemistry of CASR in human kidney tissue with CASR antibody at 5 μg/mL.
anti-CASR antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for CASR. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Predicted: 101; 120 kDa

Observed: 115; 125 kDa
NCBI Official Full Name
extracellular calcium-sensing receptor isoform 1
NCBI Official Synonym Full Names
calcium-sensing receptor
NCBI Official Symbol
NCBI Official Synonym Symbols
CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; GPRC2A; HYPOC1
  [Similar Products]
NCBI Protein Information
extracellular calcium-sensing receptor; parathyroid Ca(2+)-sensing receptor 1; parathyroid cell calcium-sensing receptor 1
UniProt Protein Name
Extracellular calcium-sensing receptor
UniProt Synonym Protein Names
Parathyroid cell calcium-sensing receptor 1; PCaR1
UniProt Gene Name
UniProt Synonym Gene Names
GPRC2A; PCAR1; CaSR; PCaR1  [Similar Products]
UniProt Entry Name
CASR_HUMAN
NCBI Summary for CASR
The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008]
UniProt Comments for CASR
CaR: a G-protein coupled receptor that activates a phosphatidylinositol-calcium second messenger system. Functions as a calcium sensor for parathyroid and kidney to determine the extracellular calcium concentration and thus helps to maintain a stable calcium concentration. Two alternatively-spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; GPCR, family 3; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3q13

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; protein binding; phosphoinositide phospholipase C activity

Biological Process: cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; ossification; anatomical structure morphogenesis; metabolic process; chemosensory behavior; detection of calcium ion

Disease: Hypocalciuric Hypercalcemia, Familial, Type I; Epilepsy, Idiopathic Generalized, Susceptibility To, 8; Hyperparathyroidism, Neonatal Severe; Hypocalcemia, Autosomal Dominant 1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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