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anti-CTSH antibody :: Rabbit Cathepsin H Polyclonal Antibody

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Catalog # MBS8229166
Unit / Price
  0.03 mL  /  $155 +1 FREE 8GB USB
  0.1 mL  /  $220 +1 FREE 8GB USB
  0.2 mL  /  $295 +1 FREE 8GB USB
Product Name

Cathepsin H (CTSH), Polyclonal Antibody

Popular Item
Full Product Name

Anti-Cathepsin H Antibody

Product Synonym Names
CPSB; Pro-cathepsin H
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
116820
3D Structure
ModBase 3D Structure for P09668
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes endogenous levels of Cathepsin H protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Source
Rabbit
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cathepsin H. The exact sequence is proprietary.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-CTSH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CTSH antibody
Rabbit polyclonal antibody to Cathepsin H
Applications Tested/Suitable for anti-CTSH antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CTSH antibody
WB (1/500 - 1/1000), IHC (1/100 - 1/200)

Western Blot (WB) of anti-CTSH antibody
Western blot analysis of Cathepsin H expression in Jurkat (A), K562 (B), mouse kidney (C), PC12 (D) whole cell lysates.
anti-CTSH antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-CTSH antibody
Immunohistochemical analysis of Cathepsin H staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
anti-CTSH antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for CTSH. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
37,394 Da
NCBI Official Full Name
pro-cathepsin H preproprotein
NCBI Official Synonym Full Names
cathepsin H
NCBI Official Symbol
NCBI Official Synonym Symbols
ACC4; ACC5; CPSB; ACC-4; ACC-5; minichain
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NCBI Protein Information
pro-cathepsin H
UniProt Protein Name
Pro-cathepsin H
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
CATH_HUMAN
NCBI Summary for CTSH
The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. [provided by RefSeq, Mar 2010]
UniProt Comments for CTSH
CTSH: Important for the overall degradation of proteins in lysosomes. Belongs to the peptidase C1 family.

Protein type: EC 3.4.22.16; Protease

Chromosomal Location of Human Ortholog: 15q25.1

Cellular Component: extracellular space; lysosome; acrosome; cytosol; outer dense fiber

Molecular Function: peptidase activity; protein binding; HLA-A specific activating MHC class I receptor activity; protein self-association; serine-type endopeptidase activity; cysteine-type endopeptidase activity; endopeptidase activity; protein complex binding; caspase activator activity; aminopeptidase activity; kininogen binding; cysteine-type peptidase activity

Biological Process: caspase activation; adaptive immune response; response to retinoic acid; protein destabilization; membrane protein proteolysis; proteolysis; antigen processing and presentation; positive regulation of angiogenesis; positive regulation of cell proliferation; zymogen activation; spermatogenesis; metanephros development; surfactant homeostasis; immune response-regulating signal transduction; T cell mediated cytotoxicity; negative regulation of apoptosis; positive regulation of cell migration
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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