NP_000204.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
106,779 Da
NCBI Official Full Name
integrin beta-4 isoform 1
NCBI Official Synonym Full Names
integrin, beta 4
NCBI Official Synonym Symbols
NCBI Protein Information
integrin beta-4; GP150; CD104 antigen; integrin beta-4 subunit
UniProt Protein Name
Integrin beta-4
UniProt Synonym Protein Names
GP150; CD_antigen: CD104
UniProt Entry Name
ITB4_HUMAN
NCBI Summary for ITGB4
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ITGB4
ITGB4: integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Five alternatively spliced isoforms have been described.
Protein type: Motility/polarity/chemotaxis; Receptor, misc.; Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17q25
Cellular Component: cell surface; hemidesmosome; leading edge; basal plasma membrane; plasma membrane; basement membrane; integrin complex; receptor complex
Molecular Function: protein binding; G-protein-coupled receptor binding; receptor activity
Biological Process: skin development; integrin-mediated signaling pathway; hemidesmosome assembly; extracellular matrix organization and biogenesis; filopodium formation; gut development; cell-matrix adhesion; cell motility involved in cell locomotion; response to wounding; mesodermal cell differentiation; autophagy; cell adhesion
Disease: Epidermolysis Bullosa, Junctional, Non-herlitz Type; Epidermolysis Bullosa Simplex, Localized; Epidermolysis Bullosa Junctionalis With Pyloric Atresia
Research Articles on ITGB4
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Products associated with anti-ITGB4 antibody
Pathways associated with anti-ITGB4 antibody
Diseases associated with anti-ITGB4 antibody
Organs/Tissues associated with anti-ITGB4 antibody
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