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anti-CD40 antibody :: Rabbit CD40 Polyclonal Antibody

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Catalog # MBS244648
Unit / Price
  0.25 mL  /  $530 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

CD40, Polyclonal Antibody

Popular Item
Also Known As

Rabbit Polyclonal (IgG) to Human CD40

Product Synonym Names
Anti-CD40 Antibody (C-Terminus) IHC-plus; CD40; B-cell surface antigen CD40; B cell-associated molecule; B cell surface antigen CD40; CD40 antigen; CD40 type II isoform; p50; Bp50; CD40L receptor; CDW40; TNFRSF5; Human CD40
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
277
OMIM
gene 606843
3D Structure
ModBase 3D Structure for P25942
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Immunoaffinity Purified
Form/Format
10 mM PBS, pH 7.4, BSA, sodium azide.
Target Species
Human
Immunogen Description
A synthetic peptide derived from C-terminal of human CD40.
Immunogen Type
Synthetic peptide
Immunogen
CD40 antibody was raised against a synthetic peptide derived from C-terminal of human CD40.
Antigen Modification
C-Terminus
Preparation and Storage
Store at 2 degree C to 8 degree C degrees. Do not freeze.
Other Notes
Small volumes of anti-CD40 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD40 antibody
CD40 is a member of the TNF-receptor superfamily. It has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions.
Product Categories/Family for anti-CD40 antibody
Applications Tested/Suitable for anti-CD40 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-CD40 antibody
IHC-P (1:100), IP, WB

Immunohistochemistry (IHC) of anti-CD40 antibody
Anti-CD40 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
anti-CD40 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for CD40. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,259 Da
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 5 isoform 1
NCBI Official Synonym Full Names
CD40 molecule, TNF receptor superfamily member 5
NCBI Official Symbol
NCBI Official Synonym Symbols
p50; Bp50; CDW40; TNFRSF5
  [Similar Products]
NCBI Protein Information
tumor necrosis factor receptor superfamily member 5; CD40L receptor; CD40 type II isoform; B cell-associated molecule; B cell surface antigen CD40; CD40 antigen (TNF receptor superfamily member 5); nerve growth factor receptor-related B-lymphocyte activation molecule
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 5
UniProt Synonym Protein Names
B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; CD_antigen: CD40
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
TNFRSF5  [Similar Products]
UniProt Entry Name
TNR5_HUMAN
NCBI Summary for CD40
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
UniProt Comments for CD40
CD40: a member of the TNF-receptor superfamily. This receptor for CD40L mediates a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. Defects in CD40 are the cause of hyper-IgM immunodeficiency type 3 (HIGM3). HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation. Two alternatively spliced isoforms have been reported. Isoform I is a type I membrane protein; isoform II is secreted.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 20q12-q13.2

Cellular Component: extracellular space; cell surface; intracellular membrane-bound organelle; integral to plasma membrane; cytoplasm; plasma membrane; external side of plasma membrane

Molecular Function: protein binding; signal transducer activity; enzyme binding; ubiquitin protein ligase binding; receptor activity; antigen binding

Biological Process: B cell proliferation; platelet activation; positive regulation of isotype switching to IgG isotypes; regulation of immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-12 production; immune response-regulating cell surface receptor signaling pathway; activation of NF-kappaB transcription factor; cellular calcium ion homeostasis; positive regulation of MAP kinase activity; positive regulation of tyrosine phosphorylation of Stat1 protein; protein kinase B signaling cascade; positive regulation of B cell proliferation; positive regulation of transcription from RNA polymerase II promoter; protein complex assembly; positive regulation of protein amino acid phosphorylation; inflammatory response; defense response to virus; regulation of immunoglobulin secretion

Disease: Immunodeficiency With Hyper-igm, Type 3
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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