NP_000551.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 24 kDa Predicted: 25 kDa
NCBI Official Full Name
leukocyte surface antigen CD53 isoform 1
NCBI Official Synonym Full Names
CD53 molecule
NCBI Protein Information
leukocyte surface antigen CD53
UniProt Protein Name
Leukocyte surface antigen CD53
UniProt Synonym Protein Names
Cell surface glycoprotein CD53; Tetraspanin-25; Tspan-25; CD_antigen: CD53
UniProt Synonym Gene Names
NCBI Summary for CD53
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
UniProt Comments for CD53
Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells ().
Research Articles on CD53
Precautions
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Disclaimer
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Products associated with anti-CD53 antibody
Diseases associated with anti-CD53 antibody
Organs/Tissues associated with anti-CD53 antibody
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