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anti-CDCA8 antibody :: Rabbit CDCA8 Polyclonal Antibody

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Catalog # MBS151409
Unit / Price
  0.1 mg  /  $375 +1 FREE 8GB USB
Product Name

CDCA8, Polyclonal Antibody

Also Known As

CDCA8 Antibody

Product Synonym Names
CDCA8; BOR; DasraB; MESRGP; BOREALIN; PESCRG3; Borealin; Cell division cycle-associated protein 8; hDasra-B; cell division cycle associated 8
Antibody/Peptide Pairs
CDCA8 peptide (MBS152863) is used for blocking the activity of CDCA8 antibody (MBS151409)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
280
OMIM
609977
3D Structure
ModBase 3D Structure for Q53HL2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
CDCA8 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (lot specific)
Conjugate
Unconjugated
Immunogen
CDCA8 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of the human CDCA8.
Buffer
CDCA8 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
CDCA8 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-CDCA8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CDCA8 antibody
CDCA8 Antibody: CDCA8 is a component of a chromosomal passenger complex (CPC) required for stability of the bipolar mitotic spindle. The chromosomal passenger complex, which includes Survivin, CDCA8, INCENP and Aurora-B, is known to play crucial roles during mitosis and cell division. It was found that CDCA8 interacting with Aurora-B, INCENP and Survivin, increases during G2/M phase and then reduces after exit from M phase. CDCA8 is cell cycle regulated, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues. In Drosophila cells, inactivation of CDCA8 results in polyploidy, delayed mitosis and abnormal tissue development, indicating its critical role for cell proliferation. Recent studies show that CDCA8 is essential for cell proliferation during early embryonic development, and its early embryonic lethality cannot be rescued by the loss of p53. Its aberrant expression is linked to a poor prognosis for gastric cancer.
Applications Tested/Suitable for anti-CDCA8 antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-CDCA8 antibody
CDCA8 antibody can be used for detection of CDCA8 by Western blot at 1 and 2 mug/mL. Antibody can also be used for immunoflourescence starting at 20 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-CDCA8 antibody
Western blot analysis of CDCA8 in Rat kidney lysate with CDCA8 antibody at (A) 1 and (B) 2 μg/mL.
anti-CDCA8 antibody Western Blot (WB) (WB) image
Immunofluorescence (IF) of anti-CDCA8 antibody
Immunofluorescence of CDCA8 in rat kidney tissue with CDCA8 antibody at 20 μg/mL.
anti-CDCA8 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for CDCA8. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31,323 Da
NCBI Official Full Name
borealin
NCBI Official Synonym Full Names
cell division cycle associated 8
NCBI Official Symbol
CDCA8  [Similar Products]
NCBI Official Synonym Symbols
BOR; DasraB; MESRGP; BOREALIN
  [Similar Products]
NCBI Protein Information
borealin; Dasra B; dasra-B; hDasra-B; cell division cycle-associated protein 8; pluripotent embryonic stem cell-related gene 3 protein
UniProt Protein Name
Borealin
UniProt Synonym Protein Names
Cell division cycle-associated protein 8; Dasra-B; hDasra-B; Pluripotent embryonic stem cell-related gene 3 protein
UniProt Gene Name
CDCA8  [Similar Products]
UniProt Synonym Gene Names
PESCRG3; hDasra-B  [Similar Products]
UniProt Entry Name
BOREA_HUMAN
NCBI Summary for CDCA8
This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]
UniProt Comments for CDCA8
Borealin: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. Belongs to the borealin family.

Protein type: Cell cycle regulation; Nucleolus

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: intercellular bridge; protein complex; nucleolus; spindle; midbody; nucleus; cytosol; chromosome, pericentric region; chromocenter

Molecular Function: protein binding

Biological Process: cell division; mitotic cell cycle; mitotic metaphase plate congression; chromosome organization and biogenesis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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