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anti-CDKN1C antibody :: Rabbit CDKN1C Polyclonal Antibody

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Catalog # MBS2522196
Unit / Price
Scan QR to view Datasheet
  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Product Name

CDKN1C, Polyclonal Antibody

Popular Item
Full Product Name

CDKN1C Polyclonal Antibody

Product Synonym Names
BWS, WBS, p57, BWCR, KIP2, IMAGE
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
130650
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
0.6mg/mL (lot specific)
Immunogen
Synthetic peptide of human CDKN1C
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-CDKN1C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CDKN1C antibody
This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.
Product Categories/Family for anti-CDKN1C antibody
Applications Tested/Suitable for anti-CDKN1C antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-CDKN1C antibody
IHC: 1:25-1:100

Immunohistochemistry (IHC) of anti-CDKN1C antibody
Immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using CDKN1C Polyclonal Antibody at dilution 1:15
anti-CDKN1C antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-CDKN1C antibody
Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CDKN1C Polyclonal Antibody at dilution 1:15
anti-CDKN1C antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for CDKN1C. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Related Accession #
Molecular Weight
31,040 Da
NCBI Official Full Name
cyclin-dependent kinase inhibitor 1C isoform b
NCBI Official Synonym Full Names
cyclin-dependent kinase inhibitor 1C (p57, Kip2)
NCBI Official Symbol
CDKN1C  [Similar Products]
NCBI Official Synonym Symbols
BWS; WBS; p57; BWCR; KIP2; p57Kip2
  [Similar Products]
NCBI Protein Information
cyclin-dependent kinase inhibitor 1C; cyclin-dependent kinase inhibitor p57
UniProt Protein Name
Cyclin-dependent kinase inhibitor 1C
UniProt Synonym Protein Names
Cyclin-dependent kinase inhibitor p57; p57Kip2
UniProt Gene Name
CDKN1C  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
CDN1C_HUMAN
NCBI Summary for CDKN1C
This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
UniProt Comments for CDKN1C
p57Kip2: Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life. Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver. Belongs to the CDI family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor; Inhibitor; Cell cycle regulation; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: cytoplasm; nucleus

Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding

Biological Process: negative regulation of kinase activity; camera-type eye development; adrenal gland development; multicellular organism growth; positive regulation of transcription, DNA-dependent; regulation of mitotic cell cycle; positive regulation of transforming growth factor beta receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; uterus development; neuron maturation; negative regulation of phosphorylation; myeloid cell differentiation; negative regulation of transcription, DNA-dependent; cell cycle arrest; kidney development; skeletal development; negative regulation of epithelial cell proliferation; aging

Disease: Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies; Beckwith-wiedemann Syndrome
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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