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anti-CHD7 antibody :: Goat CHD7 Polyclonal Antibody

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Catalog # MBS420342
Unit / Price
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  0.1 mg  /  $300 +1 FREE 8GB USB
anti-CHD7 antibody
Product Name

CHD7, Polyclonal Antibody

Popular Item
Full Product Name

Goat anti-CHD7 Antibody

Product Synonym Names
chromodomain helicase DNA binding protein 7; FLJ20357; FLJ20361; IS3; KIAA1416; Scoliosis, idiopathic 3; chromodomain helicase DNA binding protein 7 antibody; FLJ20357 antibody; FLJ20361 antibody; IS3 antibody; KIAA1416 antibody; Scoliosis; idiopathic 3 antibody
Antibody/Peptide Pairs
CHD7 peptide (MBS426334) is used for blocking the activity of CHD7 antibody (MBS420342)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
KDEIDEFANS PSE
OMIM
214800
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Human, Mouse, Rat
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-KDEIDEFANSPSE, from the internal region of the protein sequence according to NP_060250.2.
Epitope
Internal region
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CHD7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CHD7 antibody
Peptide ELISA (EIA)
Application Notes for anti-CHD7 antibody
Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Preliminary experiments gave bands at approx 250kDa and 48kDa in Rat Spinal Cord lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe given the calculated size of 336kDa according to Human NP_060250.2 and 175kDa according to predicted Rat NP_001101376.1. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).
NCBI/Uniprot data below describe general gene information for CHD7. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
101,085 Da
NCBI Official Full Name
chromodomain-helicase-DNA-binding protein 7 isoform 1
NCBI Official Synonym Full Names
chromodomain helicase DNA binding protein 7
NCBI Official Symbol
NCBI Official Synonym Symbols
CRG; HH5; IS3; KAL5
  [Similar Products]
NCBI Protein Information
chromodomain-helicase-DNA-binding protein 7
UniProt Protein Name
Chromodomain-helicase-DNA-binding protein 7
UniProt Synonym Protein Names
ATP-dependent helicase CHD7
UniProt Gene Name
UniProt Synonym Gene Names
KIAA1416; CHD-7  [Similar Products]
UniProt Entry Name
CHD7_HUMAN
NCBI Summary for CHD7
This gene encodes a protein that contains several helicase family domains. Mutations in this gene have been found in some patients with the CHARGE syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
UniProt Comments for CHD7
CHD-7: Probable transcription regulator. May interact with CTCF. Interacts with CHD8. Widely expressed in fetal and adult tissues. Belongs to the SNF2/RAD54 helicase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Helicase; DNA-binding; EC 3.6.4.12; Nucleolus

Chromosomal Location of Human Ortholog: 8q12.2

Cellular Component: nucleolus; nucleus

Molecular Function: ATP binding; chromatin binding; helicase activity; protein binding

Biological Process: adult heart development; adult walking behavior; artery morphogenesis; blood circulation; central nervous system development; chromatin modification; cognition; cranial nerve development; embryonic hindlimb morphogenesis; female genitalia development; genitalia development; heart morphogenesis; in utero embryonic development; inner ear morphogenesis; limb development; nose development; olfactory behavior; olfactory bulb development; olfactory nerve development; palate development; positive regulation of multicellular organism growth; regulation of growth hormone secretion; regulation of neurogenesis; regulation of transcription, DNA-dependent; retina development in camera-type eye; rRNA processing; semicircular canal morphogenesis; sensory perception of sound; skeletal development; T cell differentiation; transcription, DNA-dependent

Disease: Charge Syndrome; Hypogonadotropic Hypogonadism 5 With Or Without Anosmia; Tracheoesophageal Fistula With Or Without Esophageal Atresia
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-CHD7 antibody
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