NP_000740.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 53kDa Molecular Weight: 458
NCBI Official Full Name
neuronal acetylcholine receptor subunit beta-3
NCBI Official Synonym Full Names
cholinergic receptor nicotinic beta 3 subunit
NCBI Protein Information
neuronal acetylcholine receptor subunit beta-3
UniProt Protein Name
Neuronal acetylcholine receptor subunit beta-3
UniProt Entry Name
ACHB3_HUMAN
NCBI Summary for CHRNB3
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are (hetero)pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1 (MIM 100690), they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits (Groot Kormelink and Luyten, 1997 [PubMed 9009220]). Elliott et al. (1996) [PubMed 8906617] stated that the proposed structure for each subunit is a conserved N-terminal extracellular domain followed by 3 conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region.[supplied by OMIM, Apr 2010]
UniProt Comments for CHRNB3
nAChRB3: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta- 3/CHRNB3 sub-subfamily.
Protein type: Membrane protein, integral; Channel, ligand-gated; Channel, cation; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 8p11.2
Cellular Component: cell junction; integral to membrane; neuron projection; nicotinic acetylcholine-gated receptor-channel complex; plasma membrane; postsynaptic membrane
Molecular Function: acetylcholine binding; acetylcholine receptor activity; channel activity; drug binding; nicotinic acetylcholine-activated cation-selective channel activity
Biological Process: neuromuscular synaptic transmission; protein heterooligomerization; response to nicotine; signal transduction; synaptic transmission; synaptic transmission, cholinergic; transmembrane transport; transport
Research Articles on CHRNB3
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Products associated with anti-CHRNB3 antibody
Pathways associated with anti-CHRNB3 antibody
Diseases associated with anti-CHRNB3 antibody
Organs/Tissues associated with anti-CHRNB3 antibody
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