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anti-CGNL1 antibody :: Rabbit cingulin-like 1 Polyclonal Antibody

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Catalog # MBS711421
Unit / Price
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  0.05 mL  /  $230 +1 FREE 8GB USB
  0.15 mL  /  $500 +1 FREE 8GB USB
anti-CGNL1 antibody
Product Name

cingulin-like 1 (CGNL1), Polyclonal Antibody

Full Product Name

Rabbit anti-human cingulin-like 1 polyclonal Antibody

Product Synonym Names
cingulin-like 1; CGNL1; FLJ14957; JACOP; KIAA1749; MGC138254
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
607856
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Immunogen
Human CGNL1
Storage Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-162681
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-CGNL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CGNL1 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for CGNL1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
72,186 Da[Similar Products]
NCBI Official Full Name
Cingulin-like 1
NCBI Official Synonym Full Names
cingulin-like 1
NCBI Official Symbol
CGNL1  [Similar Products]
NCBI Official Synonym Symbols
JACOP
  [Similar Products]
NCBI Protein Information
cingulin-like protein 1; paracingulin; junction-associated coiled-coil protein
UniProt Protein Name
Cingulin-like protein 1
UniProt Synonym Protein Names
Junction-associated coiled-coil protein; Paracingulin
Protein Family
UniProt Gene Name
CGNL1  [Similar Products]
UniProt Synonym Gene Names
JACOP; KIAA1749  [Similar Products]
UniProt Entry Name
CGNL1_HUMAN
NCBI Summary for CGNL1
This gene encodes a member of the cingulin family. The encoded protein localizes to both adherens and tight cell-cell junctions and mediates junction assembly and maintenance by regulating the activity of the small GTPases RhoA and Rac1. Heterozygous chromosomal rearrangements resulting in association of the promoter for this gene with the aromatase gene are a cause of aromatase excess syndrome. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]
UniProt Comments for CGNL1
CGNL1: May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. Defects in CGNL1 are a cause of aromatase excess syndrome (AEXS). A disorder characterized by an estrogen excess due to an increased aromatase activity. A chromosomal aberration inv(15)(q21.2;q21.3) has been found in patients with aromatase excess syndrome. The inversion moves the promoter of the CGNL1 gene into a 5-prime position in relation to the aromatase coding region. Belongs to the cingulin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion

Chromosomal Location of Human Ortholog: 15q21.3

Cellular Component: tight junction; myosin complex

Molecular Function: motor activity

Biological Process: metabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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