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anti-CIT antibody :: Rabbit citron (rho-interacting, serine/threonine kinase 21) Polyclonal Antibody

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Catalog # MBS713299
Unit / Price
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  0.05 mL  /  $230 +1 FREE 8GB USB
  0.15 mL  /  $500 +1 FREE 8GB USB
anti-CIT antibody
Product Name

citron (rho-interacting, serine/threonine kinase 21), Polyclonal Antibody

Full Product Name

Rabbit anti-human citron (rho-interacting, serine/threonine kinase 21) polyclonal Antibody

Product Synonym Names
citron (rho-interacting; serine/threonine kinase 21); CIT; CRIK; KIAA0949; STK21
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
605629
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Immunogen
Human CIT
Storage Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-11627 / sc-11630 / sc-1949 / sc-1848
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-CIT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CIT antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
NCBI/Uniprot data below describe general gene information for CIT. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
236,607 Da[Similar Products]
NCBI Official Full Name
citron (rho-interacting, serine/threonine kinase 21), isoform CRA_b
NCBI Official Synonym Full Names
citron rho-interacting serine/threonine kinase
NCBI Official Symbol
NCBI Official Synonym Symbols
CRIK; STK21
  [Similar Products]
NCBI Protein Information
citron Rho-interacting kinase; serine/threonine kinase 21; serine/threonine-protein kinase 21; citron (rho-interacting, serine/threonine kinase 21)
UniProt Protein Name
Citron Rho-interacting kinase
UniProt Synonym Protein Names
Serine/threonine-protein kinase 21
UniProt Gene Name
UniProt Synonym Gene Names
CRIK; KIAA0949; STK21; CRIK  [Similar Products]
UniProt Entry Name
CTRO_HUMAN
NCBI Summary for CIT
This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
UniProt Comments for CIT
CRIK: an AGC kinase that is a RHO/RAC effector. Binds to the GTP-bound forms of RHO and RAC1. Required for postnatal hippocampal neurogenesis. Rho/CRIK suppresses differentiation and is associated with induction of KyoT1/2, a LIM domain protein gene implicated in integrin-mediated processes and Notch signaling. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Overexpressed in mantle-cell lymphoma (MCL), an aggressive type of B-cell lymphoma. Three alternatively spliced isoforms have been described.

Protein type: Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; AGC group; DMPK family

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: ruffle; Golgi cisterna; membrane; cell soma; plasma membrane; vacuole; actin cytoskeleton

Molecular Function: protein serine/threonine kinase activity; protein binding; Rho GTPase binding; metal ion binding; SH3 domain binding; ATP binding; PDZ domain binding

Biological Process: positive regulation of cytokinesis; mitosis; mitotic sister chromatid segregation; regulation of actin polymerization and/or depolymerization; cytokinesis; negative regulation of dendrite morphogenesis; protein amino acid phosphorylation; regulation of catalytic activity; generation of neurons; dendrite development; spermatogenesis; G2/M transition of mitotic cell cycle; Golgi organization and biogenesis; mitotic metaphase/anaphase transition
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-CIT antibody
Pathways associated with anti-CIT antibody
 Products by Pathway  Pathway Diagram
 G13 Signaling Pathway antibodies  G13 Signaling Pathway Diagram
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