EAW98156.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
citron (rho-interacting, serine/threonine kinase 21), isoform CRA_b
NCBI Official Synonym Full Names
citron rho-interacting serine/threonine kinase
NCBI Official Synonym Symbols
NCBI Protein Information
citron Rho-interacting kinase; serine/threonine kinase 21; serine/threonine-protein kinase 21; citron (rho-interacting, serine/threonine kinase 21)
UniProt Protein Name
Citron Rho-interacting kinase
UniProt Synonym Protein Names
Serine/threonine-protein kinase 21
UniProt Synonym Gene Names
UniProt Entry Name
CTRO_HUMAN
NCBI Summary for CIT
This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
UniProt Comments for CIT
CRIK: an AGC kinase that is a RHO/RAC effector. Binds to the GTP-bound forms of RHO and RAC1. Required for postnatal hippocampal neurogenesis. Rho/CRIK suppresses differentiation and is associated with induction of KyoT1/2, a LIM domain protein gene implicated in integrin-mediated processes and Notch signaling. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Overexpressed in mantle-cell lymphoma (MCL), an aggressive type of B-cell lymphoma. Three alternatively spliced isoforms have been described.
Protein type: Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; AGC group; DMPK family
Chromosomal Location of Human Ortholog: 12q24
Cellular Component: ruffle; Golgi cisterna; membrane; cell soma; plasma membrane; vacuole; actin cytoskeleton
Molecular Function: protein serine/threonine kinase activity; protein binding; Rho GTPase binding; metal ion binding; SH3 domain binding; ATP binding; PDZ domain binding
Biological Process: positive regulation of cytokinesis; mitosis; mitotic sister chromatid segregation; regulation of actin polymerization and/or depolymerization; cytokinesis; negative regulation of dendrite morphogenesis; protein amino acid phosphorylation; regulation of catalytic activity; generation of neurons; dendrite development; spermatogenesis; G2/M transition of mitotic cell cycle; Golgi organization and biogenesis; mitotic metaphase/anaphase transition
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