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anti-CLDN3 antibody :: Rabbit CLDN3 / Claudin 3 Polyclonal Antibody

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Catalog # MBS241994
Unit / Price
  0.05 mL  /  $530 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

CLDN3 / Claudin 3, Polyclonal Antibody

Also Known As

Rabbit Polyclonal (IgG) to Mouse CLDN3 / Claudin 3

Product Synonym Names
Anti-CLDN3 / Claudin 3 Antibody (C-Terminus) IHC-plus; CLDN3; C7orf1; Claudin-3; CPE-R 2; Claudin 3; RVP1; CPE-R2; CPE-receptor 2; CPETR2; HRVP1; Mouse CLDN3; Claudin 3
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
220
OMIM
602910
3D Structure
ModBase 3D Structure for O15551
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes mouse Claudin 3. Species cross-reactivity: human and rat.
Purity/Purification
Immunoaffinity Purified
Form/Format
10 mM PBS, pH 7.6, 0.2% BSA, 15 mM sodium azide, 40% glycerol.
Concentration
0.1 mg/ml (lot specific)
Target Species
Mouse
Immunogen Description
A synthetic peptide derived from the C-terminus of mouse Claudin 3. Cellular Localization: Cell membrane and cytoplasmic. MW of antigen: 22-24kD Epitope: C-terminal.
Immunogen Type
Synthetic peptide
Immunogen
CLDN3 / Claudin 3 antibody was raised against a synthetic peptide derived from the C-terminus of mouse Claudin 3. Cellular Localization: Cell membrane and cytoplasmic. MW of antigen: 22-24kD Epitope: C-terminal.
Antigen Modification
C-Terminus
Preparation and Storage
Long term: -20 degree C; Short term: +4 degree C; Avoid freeze-thaw cycles.
Other Notes
Small volumes of anti-CLDN3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-CLDN3 antibody
Applications Tested/Suitable for anti-CLDN3 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-CLDN3 antibody
IHC-P (1:100)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-CLDN3 antibody
Anti-CLDN3 / Claudin 3 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
anti-CLDN3 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for CLDN3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
23,319 Da
NCBI Official Full Name
claudin-3
NCBI Official Synonym Full Names
claudin 3
NCBI Official Symbol
CLDN3  [Similar Products]
NCBI Official Synonym Symbols
RVP1; HRVP1; C7orf1; CPE-R2; CPETR2
  [Similar Products]
NCBI Protein Information
claudin-3; CPE-R 2; CPE-receptor 2; ventral prostate.1-like protein; ventral prostate.1 protein homolog; Clostridium perfringens enterotoxin receptor 2
UniProt Protein Name
Claudin-3
UniProt Synonym Protein Names
Clostridium perfringens enterotoxin receptor 2; CPE-R 2; CPE-receptor 2; Rat ventral prostate.1 protein homolog; hRVP1
Protein Family
UniProt Gene Name
CLDN3  [Similar Products]
UniProt Synonym Gene Names
C7orf1; CPETR2; CPE-R 2; CPE-receptor 2; hRVP1  [Similar Products]
UniProt Entry Name
CLD3_HUMAN
NCBI Summary for CLDN3
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]
UniProt Comments for CLDN3
Claudin-3: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Belongs to the claudin family.

Protein type: Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: tight junction; integral to plasma membrane; integral to membrane; lateral plasma membrane

Molecular Function: identical protein binding; transmembrane receptor activity; structural molecule activity

Biological Process: response to hypoxia; signal transduction; calcium-independent cell-cell adhesion
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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