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anti-COASY antibody :: Rabbit COASY Polyclonal Antibody

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Catalog # MBS9609138
Unit / Price
  0.1 mL  /  $255 +1 FREE 8GB USB
  0.2 mL  /  $295 +1 FREE 8GB USB
Western Blot (WB)
Product Name

COASY, Polyclonal Antibody

Popular Item
Also Known As

COASY Antibody

Product Synonym Names
Bifunctional coenzyme A synthase; Bifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinase; CoA synthase; COASY; COASY_HUMAN; Coenzyme A synthase; Dephospho-CoA kinase; Dephospho-CoA pyrophosphorylase; Dephosphocoenzyme A kinase; DPCK; DPCOAK; NBP; Nucleotide binding protein; Pantetheine-phosphate adenylyltransferase; Phosphopantetheine adenylyltransferase/dephosphocoenzyme A kinase; pOV 2; POV-2; POV2; PPAT; UKR1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
564
3D Structure
ModBase 3D Structure for Q13057
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
COASY antibody detects endogenous levels of total COASY
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human COASY
Subcellular Location
Cytoplasm.
Tissue Specificity
Expressed in all tissues examined including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte. Lowest expression in peripheral blood leukocytes and highest in kidney and liver. Isoform 2 is expressed mainly in the brain.
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-COASY antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-COASY antibody
Function: Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation.
Subunit Structure: Monomer.
Similarity: In the central section; belongs to the eukaryotic CoaD family.
Applications Tested/Suitable for anti-COASY antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-COASY antibody
WB: 1:1000-3000

Western Blot (WB) of anti-COASY antibody
Western blot analysis of COASY using COS7 whole cell lysates
anti-COASY antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for COASY. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 62 kDa
Predicted: 63 kDa
NCBI Official Full Name
bifunctional coenzyme A synthase isoform a
NCBI Official Synonym Full Names
Coenzyme A synthase
NCBI Official Symbol
COASY  [Similar Products]
NCBI Official Synonym Symbols
NBP; DPCK; PPAT; UKR1; NBIA6; pOV-2
  [Similar Products]
NCBI Protein Information
bifunctional coenzyme A synthase
UniProt Protein Name
Bifunctional coenzyme A synthase
UniProt Synonym Protein Names
NBP; POV-2Including the following 2 domains:Phosphopantetheine adenylyltransferase (EC:2.7.7.3)Alternative name(s):Dephospho-CoA pyrophosphorylase; Pantetheine-phosphate adenylyltransferase; PPAT
UniProt Gene Name
COASY  [Similar Products]
UniProt Synonym Gene Names
CoA synthase; PPAT; DPCK; DPCOAK  [Similar Products]
NCBI Summary for COASY
Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA). Alternative splicing results in multiple isoforms. [provided by RefSeq, Apr 2014]
UniProt Comments for COASY
Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Diseases associated with anti-COASY antibody
Organs/Tissues associated with anti-COASY antibody
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