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anti-CCDC22 antibody :: Rabbit coiled-coil domain containing 22 Polyclonal Antibody

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Catalog # MBS719208
Unit / Price
  0.05 mL  /  $230 +1 FREE 8GB USB
  0.15 mL  /  $500 +1 FREE 8GB USB
anti-CCDC22 antibody
Product Name

coiled-coil domain containing 22 (CCDC22), Polyclonal Antibody

Also Known As

Rabbit anti-human coiled-coil domain containing 22 polyclonal Antibody

Product Synonym Names
coiled-coil domain containing 22; CCDC22; CXorf37; JM1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
627
OMIM
300859
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Immunogen
Human CCDC22
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-CCDC22 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CCDC22 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for CCDC22. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
70,756 Da[Similar Products]
NCBI Official Full Name
Coiled-coil domain containing 22
NCBI Official Synonym Full Names
coiled-coil domain containing 22
NCBI Official Symbol
CCDC22  [Similar Products]
NCBI Official Synonym Symbols
JM1; CXorf37
  [Similar Products]
NCBI Protein Information
coiled-coil domain-containing protein 22
UniProt Protein Name
Coiled-coil domain-containing protein 22
UniProt Gene Name
CCDC22  [Similar Products]
UniProt Synonym Gene Names
CXorf37  [Similar Products]
UniProt Entry Name
CCD22_HUMAN
NCBI Summary for CCDC22
This gene encodes a protein containing a coiled-coil domain. The encoded protein functions in the regulation of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) by interacting with COMMD (copper metabolism Murr1 domain-containing) proteins. The mouse orthologous protein has been shown to bind copines, which are calcium-dependent, membrane-binding proteins that may function in calcium signaling. This human gene has been identified as a novel candidate gene for syndromic X-linked intellectual disability. [provided by RefSeq, Aug 2013]
UniProt Comments for CCDC22
CCDC22: May be involved in X-linked syndromic mental retardation (PubMed:21826058). CCDC22 expression has been found to be down-regulated in a family with a phenotype consistent with X- linked syndromic mental retardation, and carrying variant Ala-17. In addition to intellectual disability, affected individuals have cardiac and skeletal abnormalities. Belongs to the CCDC22 family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: endosome

Molecular Function: protein binding

Biological Process: Golgi to plasma membrane transport; protein transport; cytoplasmic sequestering of NF-kappaB; positive regulation of I-kappaB kinase/NF-kappaB cascade; cellular copper ion homeostasis; negative regulation of I-kappaB kinase/NF-kappaB cascade
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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