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anti-CPLX2 antibody :: Rabbit CPLX2 Polyclonal Antibody

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Catalog # MBS9603598
Unit / Price
  0.1 mL  /  $255 +1 FREE 8GB USB
  0.2 mL  /  $295 +1 FREE 8GB USB
Product Name

CPLX2, Polyclonal Antibody

Popular Item
Also Known As

CPLX2 Antibody

Product Synonym Names
921 L; Complexin 2; Complexin II; Complexin-2; Complexin2; ComplexinII; CPLX 2; Cplx2; CPLX2_HUMAN; CPX 2; CPX II; CPXII; Hfb1; Synaphin 1; Synaphin-1; Synaphin1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
134
3D Structure
ModBase 3D Structure for Q6PUV4
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
CPLX2 antibody detects endogenous levels of CPLX2.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human CPLX2.
Subcellular Location
Cytoplasm > Cytosol. Enriched at synaptic-releasing sites in mature neurons.
Tissue Specificity
Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia.
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-CPLX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CPLX2 antibody
Function: Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity).
Subunit Structure: Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.
Similarity: Belongs to the complexin/synaphin family.
Applications Tested/Suitable for anti-CPLX2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CPLX2 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200

Immunohistochemistry (IHC) of anti-CPLX2 antibody
MBS9603598 at 1/100 staining Mouse brain tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
anti-CPLX2 antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-CPLX2 antibody
Western blot analysis of extracts of mouse brain tissue, using CPLX2 antibody.
anti-CPLX2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for CPLX2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 18-20 kDa
Predicted: 16 kDa
NCBI Official Full Name
complexin-2
NCBI Official Synonym Full Names
complexin 2
NCBI Official Symbol
CPLX2  [Similar Products]
NCBI Official Synonym Symbols
CPX2; Hfb1; 921-L; CPX-2
  [Similar Products]
NCBI Protein Information
complexin-2
UniProt Protein Name
Complexin-2
UniProt Synonym Protein Names
Complexin II; CPX II; Synaphin-1
Protein Family
UniProt Gene Name
CPLX2  [Similar Products]
UniProt Synonym Gene Names
CPX II  [Similar Products]
NCBI Summary for CPLX2
Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CPLX2
Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis ().
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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