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anti-CRBN antibody :: Rabbit CRBN / Cereblon Polyclonal Antibody

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Catalog # MBS249626
Unit / Price
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  0.05 mg  /  $530 +1 FREE 8GB USB
Product Name

CRBN / Cereblon, Polyclonal Antibody

Popular Item
Full Product Name

Anti-CRBN / Cereblon Antibody (C-Terminus) IHC-plus

Product Synonym Names
Rabbit Polyclonal to Human CRBN / Cereblon; Human CRBN / Cereblon; Cereblon; MRT2; MRT2A; Protein x 0001; Protein cereblon
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
607417
3D Structure
ModBase 3D Structure for Q96SW2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Rat, Human
Specificity
CRBN antibody is human, mouse and rat reactive. At least two isoforms of CRBN are known to exist; this antibody will detect both isoforms.
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, 0.02% sodium azide.
Concentration
1 mg/ml (lot specific)
Immunogen
CRBN / Cereblon antibody was raised against cRBN antibody was raised against a 16 amino acid peptide near the carboxy terminus of human CRBN.
Immunogen Description
CRBN antibody was raised against a 16 amino acid peptide near the carboxy terminus of human CRBN.
Immunogen Type
Synthetic peptide
Antigen Modification
C-Terminus
Target Species
Human
Preparation and Storage
Long term: -20 degree C
Short term: 4 degree C
Avoid repeat freeze-thaw cycles
Other Notes
Small volumes of anti-CRBN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CRBN antibody
Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1.
Applications Tested/Suitable for anti-CRBN antibody
Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes for anti-CRBN antibody
IF (20 ug/ml)
IHC-P (5 ug/ml)
WB (1 - 2 ug/ml)
ELISA (Optimal dilutions to be determined by researcher.)

Immunohistochemistry (IHC) of anti-CRBN antibody
Immunohistochemistry of CRBN in rat testis tissue with CRBN antibody at 5 ug/mL.
anti-CRBN antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-CRBN antibody
Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE)
anti-CRBN antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-CRBN antibody
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
anti-CRBN antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-CRBN antibody
Immunofluorescence of CRBN in rat testis tissue with CRBN antibody at 20 ug/mL.
anti-CRBN antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for CRBN. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,475 Da
NCBI Official Full Name
protein cereblon isoform 1
NCBI Official Synonym Full Names
cereblon
NCBI Official Symbol
NCBI Official Synonym Symbols
MRT2; MRT2A
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NCBI Protein Information
protein cereblon
UniProt Protein Name
Protein cereblon
Protein Family
UniProt Gene Name
UniProt Entry Name
CRBN_HUMAN
NCBI Summary for CRBN
This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
UniProt Comments for CRBN
CRBN: Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Defects in CRBN are the cause of mental retardation autosomal recessive type 2A (MRT2A). MRT2A patients display mild mental retardation with a standard IQ ranged from 50 to 70. IQ scores are lower in males than females. Developmental milestones are mildly delayed. There are no dysmorphic or autistic features. Non-syndromic mental retardation patients do not manifest other clinical signs. Belongs to the CRBN family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 3p26.2

Cellular Component: cytoplasm; membrane; nucleolus; nucleus

Molecular Function: ATP-dependent peptidase activity; metal ion binding; protein binding

Biological Process: negative regulation of protein homooligomerization; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination

Disease: Mental Retardation, Autosomal Recessive 2
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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