AAI07483.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Crystallin, beta B3
NCBI Official Synonym Full Names
crystallin, beta B3
NCBI Protein Information
beta-crystallin B3; eye lens structural protein
UniProt Protein Name
Beta-crystallin B3
UniProt Synonym Protein Names
Beta-B3 crystallinCleaved into the following chain:Beta-crystallin B3, N-terminally processed
UniProt Synonym Gene Names
UniProt Entry Name
CRBB3_HUMAN
NCBI Summary for CRYBB3
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B2. Mutations in this gene result in cataract congenital nuclear autosomal recessive type 2. [provided by RefSeq, Feb 2013]
UniProt Comments for CRYBB3
CRYBB3: a major structural protein of the eye lens. A member of the beta/gamma-crystallin family.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 22q11.23
Molecular Function: structural constituent of eye lens
Biological Process: visual perception
Disease: Cataract 22, Multiple Types
Research Articles on CRYBB3
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Products associated with anti-CRYBB3 antibody
Diseases associated with anti-CRYBB3 antibody
Organs/Tissues associated with anti-CRYBB3 antibody
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