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anti-CXCR3 antibody :: Goat CXCR3/GPR9 Polyclonal Antibody

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Catalog # MBS420390
Unit / Price
  0.1 mg  /  $225 +1 FREE 8GB USB
anti-CXCR3 antibody
Product Name

CXCR3/GPR9, Polyclonal Antibody

Also Known As

Goat anti-CXCR3/GPR9 Antibody

Product Synonym Names
CXCR3; chemokine (C-X-C motif) receptor 3; HGNC: 4540; CD183; CKR-L2; CMKAR3; GPR9; IP10; IP10-R; Mig-R; MigR; G protein-coupled receptor 9; IP10 receptor; Mig receptor; chemokine (C-X-C) receptor 3; CXCR3 antibody; chemokine (C-X-C motif) receptor 3 antibody; HGNC: 4540 antibody; CD183 antibody; CKR-L2 antibody; CMKAR3 antibody; GPR9 antibody; IP10 antibody; IP10-R antibody; Mig-R antibody; MigR antibody; G protein-coupled receptor 9 antibody; IP10 receptor antibody; Mig receptor antibody; chemokine (C-X-C) receptor 3 antibody; CXCR3 / GPR9
Product Synonym Gene Name
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
368
Immunogen Sequence
RRDSSWSETS EA
OMIM
300574
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Human, Mouse, Rat
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-RRDSSWSETSEA, from the C Terminus of the protein sequence according to NP_001495.1.
Epitope
C Terminus
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CXCR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CXCR3 antibody
Peptide ELISA (EIA)
Application Notes for anti-CXCR3 antibody
Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Preliminary experiments gave an approx 50-55kDa band in lysates of human thymus, kidney and placenta, and of cell line HeLa after 0.3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 40.7kDa according to NP_001495.1. The 50-55kDa band was successfully blocked by incubation with the immunizing peptide.
NCBI/Uniprot data below describe general gene information for CXCR3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,715 Da
NCBI Official Full Name
C-X-C chemokine receptor type 3 isoform 1
NCBI Official Synonym Full Names
C-X-C motif chemokine receptor 3
NCBI Official Symbol
CXCR3  [Similar Products]
NCBI Official Synonym Symbols
GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R
  [Similar Products]
NCBI Protein Information
C-X-C chemokine receptor type 3
UniProt Protein Name
C-X-C chemokine receptor type 3
UniProt Synonym Protein Names
CKR-L2; G protein-coupled receptor 9; Interferon-inducible protein 10 receptor; IP-10 receptor; CD_antigen: CD183
Protein Family
UniProt Gene Name
CXCR3  [Similar Products]
UniProt Synonym Gene Names
GPR9; CXC-R3; CXCR-3; IP-10 receptor  [Similar Products]
UniProt Entry Name
CXCR3_HUMAN
NCBI Summary for CXCR3
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
UniProt Comments for CXCR3
CXCR3: Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC). Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq13

Cellular Component: cytoplasm; cytosol; external side of plasma membrane; integral to plasma membrane; plasma membrane

Molecular Function: C-X-C chemokine binding; C-X-C chemokine receptor activity; chemokine binding; chemokine receptor activity; receptor activity

Biological Process: angiogenesis; apoptosis; calcium-mediated signaling; cell adhesion; cell motility; cell surface receptor linked signal transduction; chemotaxis; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; inflammatory response; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; positive regulation of angiogenesis; positive regulation of cAMP metabolic process; positive regulation of cell proliferation; positive regulation of chemotaxis; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of transcription from RNA polymerase II promoter; regulation of leukocyte migration
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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