NP_000095.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,846 Da
NCBI Official Full Name
cytochrome P450 1B1
NCBI Official Synonym Full Names
cytochrome P450, family 1, subfamily B, polypeptide 1
NCBI Protein Information
cytochrome P450 1B1; aryl hydrocarbon hydroxylase; cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile); flavoprotein-linked monooxygenase; microsomal monooxygenase; xenobiotic monooxygenase
UniProt Protein Name
Cytochrome P450 1B1
UniProt Synonym Protein Names
CYPIB1
UniProt Entry Name
CP1B1_HUMAN
NCBI Summary for CYP1B1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008]
UniProt Comments for CYP1B1
CYP1B1: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Defects in CYP1B1 are the cause of primary congenital glaucoma type 3A (GLC3A). GLC3A is an autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early childhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor. Defects in CYP1B1 are a cause of primary open angle glaucoma (POAG). POAG is a complex and genetically heterogeneous ocular disorder characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. In some cases, POAG shows digenic inheritance involving mutations in CYP1B1 and MYOC genes. Defects in CYP1B1 are a cause of Peters anomaly (PAN). Peters anomaly is a congenital defect of the anterior chamber of the eye. Belongs to the cytochrome P450 family.
Protein type: Amino Acid Metabolism - tryptophan; Oxidoreductase; EC 1.14.14.1; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of Human Ortholog: 2p22.2
Cellular Component: endoplasmic reticulum membrane; mitochondrion
Molecular Function: iron ion binding; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; oxygen binding; monooxygenase activity
Biological Process: steroid metabolic process; estrogen metabolic process; retinal metabolic process; collagen fibril organization; positive regulation of apoptosis; response to toxin; positive regulation of JAK-STAT cascade; negative regulation of cell proliferation; visual perception; retinol metabolic process; arachidonic acid metabolic process; angiogenesis; nitric oxide biosynthetic process; cell adhesion; negative regulation of cell adhesion mediated by integrin; negative regulation of cell migration; epoxygenase P450 pathway; positive regulation of angiogenesis; inhibition of NF-kappaB transcription factor; toxin metabolic process; xenobiotic metabolic process; endothelial cell migration; aromatic compound metabolic process; blood vessel morphogenesis; membrane lipid catabolic process; sterol metabolic process; induction of apoptosis by oxidative stress
Disease: Peters Anomaly; Glaucoma 3, Primary Congenital, A; Glaucoma 3, Primary Infantile, B
Research Articles on CYP1B1
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Products associated with anti-CYP1B1 antibody
Pathways associated with anti-CYP1B1 antibody
Diseases associated with anti-CYP1B1 antibody
Disease Name |
Pubmed Publications |
Breast Neoplasms Antibodies |
>235 publications with CYP1B1 and Breast Neoplasms |
Adenocarcinoma Antibodies |
>102 publications with CYP1B1 and Adenocarcinoma |
Lung Neoplasms Antibodies |
>79 publications with CYP1B1 and Lung Neoplasms |
Neoplasms, Experimental Antibodies |
>66 publications with CYP1B1 and Neoplasms, Experimental |
Liver Neoplasms Antibodies |
>58 publications with CYP1B1 and Liver Neoplasms |
Disease Models, Animal Antibodies |
>52 publications with CYP1B1 and Disease Models, Animal |
Glaucoma 3, Primary Congenital, A Antibodies |
>52 publications with CYP1B1 and Glaucoma 3, Primary Congenital, A |
Prostatic Neoplasms Antibodies |
>50 publications with CYP1B1 and Prostatic Neoplasms |
Inflammation Antibodies |
>46 publications with CYP1B1 and Inflammation |
Carcinoma, Squamous Cell Antibodies |
>45 publications with CYP1B1 and Carcinoma, Squamous Cell |
Organs/Tissues associated with anti-CYP1B1 antibody
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