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anti-CYP24A1 antibody :: Rabbit CYP24A1 Polyclonal Antibody

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Catalog # MBS768383 (SPECIAL PROMOTIONAL PRICING for a limited time)
Unit / Price
  0.1 mg  /  $180 +1 FREE 8GB USB
Product Name

CYP24A1, Polyclonal Antibody

Popular Item
Also Known As

CYP24A1 Rabbit Polyclonal

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
126065
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Purity: >=95% as determined by SDS-PAGE
Purificaton: Immunogen Affinity Purified
Form/Format
Liquid
Immunogen
Cytochrome P450, family 24, subfamily A, polypeptide 1
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.3
Preparation and Storage
Store at -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-CYP24A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CYP24A1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
Application Notes for anti-CYP24A1 antibody
WB: 1:200-1:2000
IP: 1:200-1:1000
IHC: 1:20-1:200

Immunohistochemistry of anti-CYP24A1 antibody
Immunohistochemistry of paraffin-embedded human kidney using MBS768383 (CYP24A1 antibody) at dilution of 1:50
anti-CYP24A1 antibody Immunohistochemistry (IHC) image
Western Blot of anti-CYP24A1 antibody
HeLa cells were subjected to SDS PAGE followed by western blot with MBS768383 (CYP24A1 antibody) at dilution of 1:300
anti-CYP24A1 antibody Western Blot (WB) image
NCBI/Uniprot data below describe general gene information for CYP24A1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59kDa
NCBI Official Full Name
CYP24A1 protein
NCBI Official Synonym Full Names
cytochrome P450 family 24 subfamily A member 1
NCBI Official Symbol
CYP24A1  [Similar Products]
NCBI Official Synonym Symbols
CP24; HCAI; CYP24; HCINF1; P450-CC24
  [Similar Products]
NCBI Protein Information
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
UniProt Protein Name
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
UniProt Synonym Protein Names
Cytochrome P450 24A1; Cytochrome P450-CC24
UniProt Gene Name
CYP24A1  [Similar Products]
UniProt Synonym Gene Names
CYP24; 24-OHase; Vitamin D(3) 24-hydroxylase  [Similar Products]
UniProt Entry Name
CP24A_HUMAN
NCBI Summary for CYP24A1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CYP24A1
CYP24A1: Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product. Defects in CYP24A1 are the cause of hypercalcemia infantile (HCAI). HCAI is a disorder characterized by abnormally high level of calcium in the blood, failure to thrive, vomiting, dehydration, and nephrocalcinosis. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.13.126; Oxidoreductase; Mitochondrial

Chromosomal Location of Human Ortholog: 20q13

Cellular Component: mitochondrial inner membrane; mitochondrion; nucleoplasm; nucleus; plasma membrane

Molecular Function: 1-alpha,25-dihydroxyvitamin D3 (1,25-(OH)2D3) 24-hydroxylase activity; 25-hydroxycholecalciferol-24-hydroxylase activity; heme binding; iron ion binding; oxidoreductase activity

Biological Process: osteoblast differentiation; response to vitamin D; vitamin D catabolic process; vitamin D metabolic process; vitamin metabolic process

Disease: Hypercalcemia, Infantile
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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